| Diploid growth pattern of hepatocellular tumours induced by various carcinogenic treatments. | |
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MedLine Citation:
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PMID: 1847321 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hepatocellular carcinomas from rats of different strains, subjected to a variety of carcinogenic treatment regimens in different laboratories (initiation by diethylnitrosamine or dimethylhydrazine, promotion by phenobarbital, 2-acetylaminofluorene, nafenopin, orotic acid or deoxycholic acid, growth stimulation by partial hepatectomy or necrogenic CCl4 treatment), were all found to be predominantly diploid by flow cytometric analysis, in contrast to normal liver tissue in which polyploid nuclei were predominant. A switch from polyploidization to diploid growth would thus seem to be a common property of malignant liver tumours. Benign neoplastic liver nodules were likewise predominantly diploid, with the exception of nodules induced by long-term deoxycholic acid treatment in Fischer rats. In addition to containing a majority of polyploid cells, the latter nodules failed to progress to the carcinoma stage. |
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Authors:
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P E Schwarze; G Saeter; D Armstrong; R G Cameron; E Laconi; D S Sarma; V Préat; P O Seglen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Carcinogenesis Volume: 12 ISSN: 0143-3334 ISO Abbreviation: Carcinogenesis Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1991-03-25 Completed Date: 1991-03-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 325-7 Citation Subset: IM |
Affiliation:
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Department of Tissue Culture, Norwegian Radium Hospital, Oslo. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinogens / toxicity* Carcinoma, Hepatocellular / chemically induced, genetics* Cell Division / physiology Diploidy Flow Cytometry Liver Neoplasms, Experimental / chemically induced, genetics* Ploidies Rats Rats, Inbred F344 Rats, Inbred Strains Rats, Inbred WKY |
| Grant Support | |
ID/Acronym/Agency:
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CA 37077/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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