| Diphenylhydantoin teratogenicity in man. | |
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MedLine Citation:
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PMID: 733136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case is presented of fetal teratogenic damage from an unusually high maternal dosage of diphenylhydantoin, 600 mg daily, to a 40-kg woman throughout pregnancy. The anomalies included narrowed ends of the fingers and toes; aplasia of the nails on the other fingers and toes; aplasia of the distal phalanges of the fingers and toes; a broad, depressed nasal bridge; anteverted nostrils; prominent upper lip; coarse, profuse scalp hair; pilonidal sinus; and simian crease of the left hand. At the age of 7 months, ossification of the distal phalanges of both middle fingers appeared, the anterior fontanel was small, brain development was retarded, cranial asymmetry was marked, and the fingertips showed a pattern of low arch dermal ridges. |
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Authors:
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T S Yang; C C Chi; C J Tsai; M J Chang |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 52 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 1978 Dec |
Date Detail:
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Created Date: 1979-03-24 Completed Date: 1979-03-24 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 682-4 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology* Abnormalities, Multiple / chemically induced* Adult Female Fingers / abnormalities Humans Infant Infant, Newborn Lip / abnormalities Male Nails, Malformed Nose / abnormalities Phenytoin / adverse effects* Pregnancy Thumb / abnormalities Toes / abnormalities |
| Chemical | |
Reg. No./Substance:
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57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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