| Diphenylhydantoin-induced severe yet reversible anemia during pregnancy. | |
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MedLine Citation:
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PMID: 21088360 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Diphenylhydantoin (DPH) therapy, often used in treating epileptic seizures, can cause anemia in some patients. A 26-year-old female suffered from convulsions due to encephalitis and was placed on DPH therapy. About two months after the initiation of DPH therapy, her hemoglobin level was 3.8 g/dL. Her anemia improved after the discontinuation of DPH, confirming that the anemia was caused by DPH. Pure red-cell aplasia (PRCA) combined with hemolytic anemia was indicated by results such as erythroid aplasia, an increased LDH level, and a decreased haptoglobin level. PRCA complicated by hemolytic anemia could be responsible for anemia associated with DPH. |
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Authors:
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Akinori Sugaya; Kiyotaka Nakamagoe; Yasushi Okoshi; Mana Obata-Yasuoka; Akira Tamaoka |
Publication Detail:
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Type: Journal Article Date: 2010-11-15 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 49 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 2515-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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