| Diphenyl diselenide-modulation of macrophage activation: Down-regulation of classical and alternative activation markers. | |
| | |
MedLine Citation:
|
PMID: 22215443 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Diphenyl diselenide (PhSe)(2), a simple organoselenium compound, possesses interesting pharmacological properties that are under extensive research. As macrophages respond to microenvironmental stimuli and can display activities engaged in the initiation and the resolution of inflammation, in the present report we describe the ability of (PhSe)(2) to modulate the macrophage activation. Our data indicate that (PhSe)(2) could inhibit the NO production in a dose-dependent fashion in peritoneal macrophages activated by LPS or treated with vehicle alone. We could demonstrate that this effect correlated with a reduction in the expression of the inducible NO synthase in (PhSe)(2)-treated cells. Furthermore, (PhSe)(2) suppressed the production of reactive oxygen species, diminished the activity of the arginase enzyme, and the accumulation of nitrotyrosine modified proteins in LPS-stimulated macrophages. This compound also diminished the antigen presentation capacity of classically activated macrophages, as it reduced MHCII and CD86 expression. In addition, (PhSe)(2) modulated the alternative activation phenotype of macrophages. Dexamethasone-activated macrophages presented higher production of IL-10 and CD206, which were both down-regulated by the addition of (PhSe)(2). These results suggest that (PhSe)(2) possesses antioxidant and anti-inflammatory activities in classically-activated macrophages. We could demonstrate that (PhSe)(2) can be also utilized to modulate the alternative activation phenotype of macrophages. |
| | |
Authors:
|
Lucía L Rupil; Andreza F de Bem; German A Roth |
Related Documents
:
|
19533603 - Selective estrogen receptor modulators decrease the production of interleukin-6 and int... 9581803 - Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide mo... 19840863 - The role of hif in immunity. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-3 |
Journal Detail:
|
Title: Innate immunity Volume: - ISSN: 1753-4267 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101469670 Medline TA: Innate Immun Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Departamento de Química Bioloógica, Universidad Nacional de Córdoba, Córdoba, Argentina. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and ...
Next Document: The birth and early growth of a comprehensive multidisciplinary diabetes center in a community hospi...