| Diphenyl diselenide behaves differently than ebselen under different pH media in rat's liver preparations. | |
| | |
MedLine Citation:
|
PMID: 20188485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The anti-oxidant potential of diphenyl diselenide and ebselen against low pH-mediated peroxidation processes in rat's liver preparation are unknown. For this purpose, we have determined anti-oxidant activities of both compounds at a range of various pH (7.4-5.4) values. Low pH increased the rate of lipid peroxidation in the absence of Fe(+2) (20 micromol) in liver homogenates. This higher extent of lipid peroxidation can be explained by the mobilized iron, which may come from reserves where it is weakly bound. The addition of iron (Fe) chelator desferoxamine (DFO, 1 mmol) to reaction medium completely inhibited the peroxidation processes at all studied pH values. Diphenyl diselenide (0-100 micromol) significantly protected lipid peroxidation at all studied pH values, while ebselen (0-100 micromol) did not offer any protection. The differences in activities of diphenyl diselenide and ebselen have been explained with reference to the active selenol formation using their catalytic reactions. The anti-oxidant potential of diphenyl diselenide is confirmed against acidosis-catalyzed oxidative stress in rat liver homogenates. |
| | |
Authors:
|
Waseem Hassan; Mohammad Ibrahim; Joao Batista Teixeira Rocha |
Related Documents
:
|
9379345 - Melatonin's antioxidant protection against delta-aminolevulinic acid-induced oxidative ... 18004455 - Swallow-tailed perylene derivative: a new tool for fluorescent imaging of lipid hydrope... 1910315 - Mechanism of cobalt (ii) ion inhibition of iron-supported phospholipid peroxidation. 1653565 - Phenolic compounds and an analog as superoxide anion scavengers and antioxidants. 15822995 - Application of vinyl tris(trimethylsilyl)germanes in pd-catalyzed couplings. 21815685 - Total synthesis of (-)-4,8,10-tridesmethyl telithromycin. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-25 |
Journal Detail:
|
Title: Pathology, research and practice Volume: 206 ISSN: 1618-0631 ISO Abbreviation: Pathol. Res. Pract. Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-31 Completed Date: 2010-08-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7806109 Medline TA: Pathol Res Pract Country: Germany |
Other Details:
|
Languages: eng Pagination: 357-60 Citation Subset: IM |
Copyright Information:
|
2010 Elsevier GmbH. All rights reserved. |
Affiliation:
|
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil. waseem_anw@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antioxidants / pharmacology* Azoles / pharmacology* Benzene Derivatives / pharmacology* Hydrogen-Ion Concentration Lipid Peroxidation / drug effects Liver / drug effects*, metabolism* Male Organoselenium Compounds / pharmacology* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Azoles; 0/Benzene Derivatives; 0/Organoselenium Compounds; 1666-13-3/diphenyldiselenide; 60940-34-3/ebselen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cleft lip and palate: An adverse pregnancy outcome due to undiagnosed maternal and paternal coeliac ...
Next Document: Revisiting old slides - How worthwhile is it?