Document Detail

Diphenyl diselenide behaves differently than ebselen under different pH media in rat's liver preparations.
MedLine Citation:
PMID:  20188485     Owner:  NLM     Status:  MEDLINE    
The anti-oxidant potential of diphenyl diselenide and ebselen against low pH-mediated peroxidation processes in rat's liver preparation are unknown. For this purpose, we have determined anti-oxidant activities of both compounds at a range of various pH (7.4-5.4) values. Low pH increased the rate of lipid peroxidation in the absence of Fe(+2) (20 micromol) in liver homogenates. This higher extent of lipid peroxidation can be explained by the mobilized iron, which may come from reserves where it is weakly bound. The addition of iron (Fe) chelator desferoxamine (DFO, 1 mmol) to reaction medium completely inhibited the peroxidation processes at all studied pH values. Diphenyl diselenide (0-100 micromol) significantly protected lipid peroxidation at all studied pH values, while ebselen (0-100 micromol) did not offer any protection. The differences in activities of diphenyl diselenide and ebselen have been explained with reference to the active selenol formation using their catalytic reactions. The anti-oxidant potential of diphenyl diselenide is confirmed against acidosis-catalyzed oxidative stress in rat liver homogenates.
Waseem Hassan; Mohammad Ibrahim; Joao Batista Teixeira Rocha
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-25
Journal Detail:
Title:  Pathology, research and practice     Volume:  206     ISSN:  1618-0631     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-31     Completed Date:  2010-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  357-60     Citation Subset:  IM    
Copyright Information:
2010 Elsevier GmbH. All rights reserved.
Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil.
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MeSH Terms
Antioxidants / pharmacology*
Azoles / pharmacology*
Benzene Derivatives / pharmacology*
Hydrogen-Ion Concentration
Lipid Peroxidation / drug effects
Liver / drug effects*,  metabolism*
Organoselenium Compounds / pharmacology*
Rats, Wistar
Reg. No./Substance:
0/Antioxidants; 0/Azoles; 0/Benzene Derivatives; 0/Organoselenium Compounds; 1666-13-3/diphenyldiselenide; 60940-34-3/ebselen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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