| Diphenyl Diselenide Effectively Reduces Atherosclerotic Lesion in LDLr-/- Mice by Attenuation of Oxidative Stress and Inflammation. | |
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MedLine Citation:
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PMID: 21558882 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Glutathione peroxidase (GPx) plays an important role in the antioxidant defense of the vascular wall and its deficiency has been implicated in the development of atherosclerotic lesions. The present study analyzed the potential of diphenyl diselenide (DD), a simple organoselenium compound with GPx-like activity, to reduce atherosclerosis. Herein, we demonstrate that oral treatment with low doses of DD potently reduced the formation of atherosclerotic lesion in hypercholesterolemic LDL receptor knockout (LDLr -/-) mice. This reduction was accompanied by significantly improved endothelium-dependent vasorelaxation, lower nitrotyrosine and MDA levels, decrease in vessel wall infiltration by inflammatory cells and prevention of upregulation of the proatherogenic monocyte chemoattractant protein-1 (MCP-1). Studies in J774 macrophage-like cells show that DD significantly decreased oxLDL-induced formation of foam cells and the generation of ROS and inflammatory mediators. Our results reveal the antiatherogenic actions of DD by modulating intracellular signaling pathways related to antioxidant and anti-inflammatory responses. |
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Authors:
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Mariana Appel Hort; Marcos Raniel Straliotto; Paula Moro Netto; João Batista Teixeira da Rocha; Andreza Fabro de Bem; Rosa Maria Ribeiro-do-Valle |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-06 |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: - ISSN: 1533-4023 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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* Department of Pharmacology, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis, SC, Brazil; †Department of Biochemistry, Biological Sciences Center, Federal University of Santa Catarina, Florianópolis, SC, Brazil; § Department of Chemistry, Federal University of Santa Maria, Santa Maria, RS, Brazil. |
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