| Dipeptide metabolism in the isolated perfused rat small intestine. | |
| | |
MedLine Citation:
|
PMID: 16839952 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The purpose of the present study was to investigate the utilisation of vascularly administered leucyl-leucine (Leu-Leu), alanyl-glutamine (Ala-Gln) and glycyl-glutamine (Gly-Gln) by the isolated vascularly perfused rat small intestine. Fractional extraction rates were 49%, 35.5%, and 12% for Leu-Leu, Ala-Gln, and Gly-Gln (0.15mM) corresponding to a net uptake of -63.5, -31.5, and -17 nmol/min/g wet weight. Nitrogen metabolism in terms of glutamine uptake and release of alanine and ammonia was not different when perfusion with dipeptides or with free amino-acids were compared. No soluble dipeptidase activity was released into the plasma- and cell-free synthetic vascular perfusate. No dipeptide could be recovered from the luminal perfusate. Considering the high fractional extraction rate for Leu-Leu, it is conceivable that dipeptide assimilation may occur also in extramucosal gut tissue. Although dipeptide transport cannot be excluded, dipeptide assimilation in small intestine may involve membrane bound peptidase(s), as in liver. |
| | |
Authors:
|
M Plauth; I Kremer; A Raible; P Stehle; P Fürst; F Hartmann |
Publication Detail:
|
Type: Editorial |
Journal Detail:
|
Title: Clinical nutrition (Edinburgh, Scotland) Volume: 10 Suppl ISSN: 0261-5614 ISO Abbreviation: Clin Nutr Publication Date: 1991 |
Date Detail:
|
Created Date: 2006-07-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8309603 Medline TA: Clin Nutr Country: England |
Other Details:
|
Languages: eng Pagination: 25-32 Citation Subset: - |
Affiliation:
|
Eberhard-Karls-Universität, Medizinische Klinik und Poliklinik, Abteilung Innere Medizin I, D-7400 Tübingen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Measurement of albumin synthesis in perfused rat liver using stable isotopes: [15N] hippurate as a m...
Next Document: Role of membrane transport in the regulation of skeletal muscle glutamine turnover.