| Dipeptide Tyr-Leu (YL) exhibits anxiolytic-like activity after oral administration via activating serotonin 5-HT1A, dopamine D1 and GABAA receptors in mice. | |
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MedLine Citation:
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PMID: 20005875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We found that Tyr-Leu (YL) dose-dependently exhibits potent anxiolytic-like activity (0.1-1mg/kg, i.p.) comparable to diazepam in the elevated plus-maze test in mice. YL was orally active (0.3-3mg/kg). A retro-sequence peptide or a mixture of Tyr and Leu was inactive. The anxiolytic-like activity of YL was inhibited by antagonists for serotonin 5-HT(1A), dopamine D(1) and GABA(A) receptors; however, YL had no affinity for them. We also determined the order of their activation is 5-HT(1A), D(1) and GABA(A) receptors using selective agonists and antagonists. Taken together, YL may exhibit anxiolytic-like activity via activation of 5-HT(1A), D(1) and GABA(A) receptors. |
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Authors:
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Norimasa Kanegawa; Chihiro Suzuki; Kousaku Ohinata |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-23 |
Journal Detail:
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Title: FEBS letters Volume: 584 ISSN: 1873-3468 ISO Abbreviation: FEBS Lett. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-01-27 Completed Date: 2010-02-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 599-604 Citation Subset: IM |
Copyright Information:
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2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Anti-Anxiety Agents / administration & dosage, pharmacology* Dipeptides / administration & dosage, pharmacology Male Maze Learning / drug effects Mice Receptor, Serotonin, 5-HT1A / metabolism* Receptors, Dopamine D1 / metabolism* Receptors, GABA-A / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 0/Dipeptides; 0/Receptors, Dopamine D1; 0/Receptors, GABA-A; 112692-38-3/Receptor, Serotonin, 5-HT1A; 17355-10-1/tyrosylleucine |
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