Document Detail


Dioxygenase and peroxidase activities of soybean lipoxygenase: synergistic interaction between linoleic acid and hydrogen peroxide.
MedLine Citation:
PMID:  2513625     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The interaction of H2O2 with soyabean lipoxygenase was investigated in the presence of linoleic acid. Dioxygenase activity was significantly higher at pH 9.0 than at pH 6.0. H2O2 at concentrations less than 1.0 nM stimulated linoleic acid oxidation synergistically and the magnitude of synergism was higher at pH 9.0. Linoleic acid dependent peroxidase activity towards benzidine, guaiacol, tetramethylbenzidine (TMBD) and tetramethylphenylenediamine (TMPD) was higher at pH 9.0, whereas pyrogallol and ABTS oxidation rates were higher at pH 6.0. H2O2 supported oxidation of benzidine, guaiacol, pyrogallol and ABTS was higher at pH 6.0, whereas TMPD, TMBD exhibited higher oxidation rates at pH 9.0. H2O2 in the presence of linoleic acid produced synergism in xenobotic metabolism and depending upon the substrate in question upto 11-fold increase in oxidation rate was noted.
Authors:
A P Kulkarni; J Chaudhuri; A Mitra; I S Richards
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  66     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-01-31     Completed Date:  1990-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  287-96     Citation Subset:  IM    
Affiliation:
Florida Toxicology Research Center, College of Public Health, University of South Florida, Tampa 33612.
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MeSH Terms
Descriptor/Qualifier:
Drug Synergism
Hydrogen Peroxide / pharmacology*
Linoleic Acids / pharmacology*
Lipoxygenase / metabolism*
Oxygenases / metabolism
Peroxidases / metabolism
Soybeans / enzymology*
Chemical
Reg. No./Substance:
0/Linoleic Acids; 7722-84-1/Hydrogen Peroxide; EC 1.11.1.-/Peroxidases; EC 1.13.-/Oxygenases; EC 1.13.11.12/Lipoxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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