Document Detail

Dioxin-like exposures and effects on estrogenic and androgenic exposures and micronuclei frequency in mother-newborn pairs.
MedLine Citation:
PMID:  20189248     Owner:  NLM     Status:  MEDLINE    
In utero exposure to environmental dioxin-like, estrogen and androgen compounds can cause adverse health effects. Little is known about potential interactions in vivo between dioxin-like compounds, estrogens and androgens during fetal development in humans. Therefore we explored the potential interactions in vivo between dioxin-like compounds, estrogens, androgens using chemical-activated luciferase expression (CALUX)(R) bioassays in maternal and umbilical cord blood plasma concurrently collected at the time of planned Caesarean section from 98 healthy pregnancies. The dioxin-like activity was also determined after placental transfer of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the ex vivo human placenta perfusion system. Similar dioxin-like activity in maternal and cord blood (37 versus 33pg CALUX(R)-TEQ/g plasma lipids, P>0.05) was detected and it demonstrates transplacental transfer. Increased dioxin-like activity in the perfused placenta tissue after ex vivo TCDD perfusions (from 17 to 280pg CALUX(R)-TEQ/g plasma lipids) suggest that accumulation in the placenta prevents immediate transplacental transfer of TCDD. Androgenic activity were also similar in the paired mother-newborns (0.10 versus 0.18ng CALUX(R)-AEQ/mL plasma), whereas cord blood plasma estrogenic activity was higher than maternal levels (22.6 versus 18.5ng CALUX(R)-EEQ/mL plasma). In cord blood plasma androgenic activity was strongly positively associated with maternal levels (Rs=0.8, P<0.001) whereas dioxin-like and estrogenic activities were modestly associated with maternal levels (Rs</=0.4, P<0.001). The micronuclei frequency, an indicator of genetic instability was significantly associated with dioxin-like activity in cord blood, independently of other recorded factors (Rs=0.4, P<0.003). This study demonstrated interactions in vivo between dioxin-like, estrogenic and androgenic exposures during fetal development of humans.
Marie Pedersen; Thorhallur I Halldorsson; Line Mathiesen; Tina Mose; Abraham Brouwer; Morten Hedegaard; Steffen Loft; Jos C S Kleinjans; Harrie Besselink; Lisbeth E Knudsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-26
Journal Detail:
Title:  Environment international     Volume:  36     ISSN:  1873-6750     ISO Abbreviation:  Environ Int     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-06-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7807270     Medline TA:  Environ Int     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  344-51     Citation Subset:  IM    
Section of Environmental Health, Department of Public Health, University of Copenhagen, Oester Farimagsgade 5A, 1353 Copenhagen K, Denmark. <>
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MeSH Terms
Androgens / toxicity*
Biological Assay / methods
Dioxins / toxicity*
Environmental Exposure*
Environmental Pollutants / toxicity*
Estrogens / toxicity*
Gene Expression / drug effects
Genes, Reporter
Infant, Newborn
Luciferases / biosynthesis,  genetics
Micronuclei, Chromosome-Defective / chemically induced*
Placenta / chemistry
Plasma / chemistry
Young Adult
Reg. No./Substance:
0/Androgens; 0/Dioxins; 0/Environmental Pollutants; 0/Estrogens; EC 1.13.12.-/Luciferases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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