Document Detail

Dioxin and dioxin-like PCB exposure of non-breastfed Dutch infants.
MedLine Citation:
PMID:  16442144     Owner:  NLM     Status:  MEDLINE    
The exposure of humans to PCDD/Fs (polychlorinated dibenzo-p-dioxins and dibenzofurans) and dioxin-like PCBs (dl-PCBs, i.e. polychlorinated non-ortho and mono-ortho biphenyls) occurs predominantly via the intake of food. Young children have a relatively high intake of these substances, due to their high food consumption per kilogram body weight. As the exposure of non-breastfed infants to these compounds has not been assessed before in The Netherlands, we studied the dietary intake of 17 PCDD/Fs and 11 dioxin-like PCBs in 188 Dutch non-breastfed infants between 4 and 13 months. The food intake of the infants was assessed by a 2-d food record. From these data PCDD/F and dioxin-like PCB intake was calculated using PCDD/F and dioxin-like PCB concentrations of food products sampled in 1998/1999 in The Netherlands. The long-term PCDD/F and dioxin-like PCB exposure of the infants was calculated using the statistical exposure model (STEM). For infants of 5 months the chronic exposure to PCDD/F and dioxin-like PCB was 1.1pg WHO-TEQ (toxic equivalents) per kilogram body weight (bw) per day (95th percentile: 1.7pg WHO-TEQ/kg bwxd), which mainly originated from infant formula and vegetables and increased to 2.3pg WHO-TEQ/kg bwxd (95th percentile 3.7pg WHO-TEQ/kg bwxd) for infants just over 1 year old eating the same food as their parents. The percentage of formula-fed infants with an exposure exceeding the TDI of 2pg WHO-TEQ/kg bwxd was 5% at 5 months, 49% at 9 months and 64% at 12 months.
P J M Weijs; M I Bakker; K R Korver; K van Goor Ghanaviztchi; J H van Wijnen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-25
Journal Detail:
Title:  Chemosphere     Volume:  64     ISSN:  0045-6535     ISO Abbreviation:  Chemosphere     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-24     Completed Date:  2006-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0320657     Medline TA:  Chemosphere     Country:  England    
Other Details:
Languages:  eng     Pagination:  1521-5     Citation Subset:  IM    
Hogeschool van Amsterdam, Amsterdam School of Nutrition and Dietetics, Dr. Meurerlaan 8, 1067 SM Amsterdam, The Netherlands.
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MeSH Terms
Dioxins / analysis*
Environmental Exposure / analysis*
Environmental Pollutants / analysis*
Food Contamination / analysis*
Infant Food / analysis*,  standards
Polychlorinated Biphenyls / analysis*
Reg. No./Substance:
0/Dioxins; 0/Environmental Pollutants; 0/Polychlorinated Biphenyls

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