| Diode laser cycloablation in adult glaucoma: long-term results of a standard protocol and review of current literature. | |
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MedLine Citation:
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PMID: 16872335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: To study the long-term efficacy and safety of diode laser cycloablation under a standard protocol in refractory glaucoma. METHODS: A retrospective study involving 42 eyes (39 patients), observed for 36-84 (mean 65.7) months after cycloablation involving 14 burns of 2-W power and 2-s duration, over 270 degrees of the ciliary body. RESULTS: By final review, mean intraocular pressure (IOP) had dropped by 50.3% from 31.4 +/- 8.8 mmHg before treatment to 15.6 +/- 6.3 mmHg (P < 0.0001). Thirty-seven of the 42 eyes (88.1%) achieved IOP < 22 mmHg. Thirty-five of the 42 eyes (83.3%) eyes achieved IOP reduction > or = 30% from baseline levels. The mean number of antiglaucoma medications per eye dropped from 2.55 +/- 0.83 to 1.71 +/- 1.44 (P = 0.0004). The percentage of eyes requiring oral acetazolamide dropped from 92.9% to 11.9% (P < 0.0001). About 59.6% of eyes required multiple treatment sessions (mean 2.17). Twenty-seven (64.3%) eyes suffered deterioration, 11 (26.2%) maintained stability and 4 (9.5%) exhibited improvement of visual acuity. No relationship between the number of treatment sessions and visual outcome was evident. CONCLUSIONS: This conservative repeatable protocol affords delivery of the minimum dose of photocoagulation necessary to achieve a safe, long-term ocular hypotensive response, while minimizing the risk of serious adverse effects, and is valuable in the difficult treatment of refractory glaucoma. |
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Authors:
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Stephen A Vernon; Joanne M Koppens; G Jayakrishna Menon; Anil K Negi |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical & experimental ophthalmology Volume: 34 ISSN: 1442-6404 ISO Abbreviation: Clin. Experiment. Ophthalmol. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-07-28 Completed Date: 2006-09-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100896531 Medline TA: Clin Experiment Ophthalmol Country: Australia |
Other Details:
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Languages: eng Pagination: 411-20 Citation Subset: IM |
Affiliation:
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Directorate of Ophthalmology, Queens Medical Centre, Nottingham, UK. stephen.vernon@nuh.nhs.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
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therapeutic use Adolescent Adult Aged Aged, 80 and over Carbonic Anhydrase Inhibitors / therapeutic use Ciliary Body / surgery* Drug Utilization Female Glaucoma, Open-Angle / drug therapy, physiopathology, surgery* Humans Intraocular Pressure / physiology Laser Coagulation / methods* Male Middle Aged Retrospective Studies Visual Acuity / physiology |
| Chemical | |
Reg. No./Substance:
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0/Carbonic Anhydrase Inhibitors; 59-66-5/Acetazolamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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