Document Detail

Dinoprostone versus misoprostol: a randomized study of nulliparous women undergoing induction of labor.
MedLine Citation:
PMID:  12648174     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The objectives of the study were to compare the efficacy and safety of intravaginal misoprostol and intravaginal dinoprostone for induction of labor and to quantify the clinical response to suspicious cardiotocographic (CTG) readings. METHODS: One hundred and ninety-one patients were randomized to receive either 50 micro g misoprostol initially then a further identical dose 6 h later or 2 mg dinoprostone initially followed by 1 mg 6 h later, over a period of 24 h. If not in labor after 24 h, then both arms of the study would thereafter receive dinoprostone alone as per hospital protocol. RESULTS: The induction to delivery interval (1047 vs. 1355 min, p = 0.01), delivery within 12 h (35.4% vs. 18.9%, p = 0.02) and delivery within 24 h (83.3% vs. 63.3%, p = 0.01) were all shorter in the misoprostol arm. There were no differences in rates of oxytocin augmentation (p = 0.47), tachysystole (p = 0.32) and hyperstimulation syndrome (p = 0.82). There was an increase in the median number of times a doctor was called to advise on a suspicious CTG in the misoprostol group (1 vs. 2 occasions, p = 0.052), but there was no difference in neonatal outcome. CONCLUSIONS: Intravaginal misoprostol led to a shorter, more efficient labor, and although there was more anxiety related to the CTG, there was no increase in neonatal adverse effects.
Amali U Lokugamage; Sophie F Forsyth; Keith R Sullivan; Hazem El Refaey; Charles H Rodeck
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  82     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-21     Completed Date:  2003-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  133-7     Citation Subset:  IM    
Department of Obstetrics & Gynecology, Royal Free & University College London Medical School, University College London, London, UK.
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MeSH Terms
Administration, Intravaginal
Cardiotocography / drug effects
Cervical Ripening / drug effects
Dinoprostone / administration & dosage*,  adverse effects
Labor, Induced / methods*
Labor, Obstetric
Middle Aged
Misoprostol / administration & dosage*,  adverse effects
Oxytocics / administration & dosage*,  adverse effects
Pregnancy Outcome
Reg. No./Substance:
0/Oxytocics; 363-24-6/Dinoprostone; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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