Document Detail


Dinoprostone vaginal slow-release system (Propess) compared to expectant management in the active treatment of premature rupture of the membranes at term: impact on maternal and fetal outcomes.
MedLine Citation:
PMID:  18231888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Retrospective study of 744 women at the Virgen del Camino Hospital in Pamplona concerning two variants for the active treatment of premature rupture of the membranes (PROM). The main purpose of the study was to assess the differences between two variants for the active treatment of PROM at term in pregnant women with negative vaginal-rectal culture screening for Group B Streptococci, and a Bishop test of 4 or less on admission. METHODS: Retrospective study of 744 patients with single pregnancy at term, PROM, and Bishop test <4. The patients, who were not randomised, were treated with dinoprostone (Propess) or expectant therapy, according to the physician's choice. Induction with oxytocin was started 12 h after PROM. Qualitative data were analysed using the chi(2) test, while quantitative data were analysed using the Student's t-test or the Mann-Whitney U-test according to the distribution of the variables. Regression models were applied to correct the biases caused by confounding variables. RESULTS: Of the 744 patients, the cervix of 13% was maturated with pericervical dinoprostone, while 87% were subject to expectant management until 12 h after rupture of the membranes. The time of dilation and the time until labour were significantly shorter in the dinoprostone group (p=0.0). The rate of caesarean sections was also lower in the dinoprostone group at 9.3% compared to 17.6% in the expectant management group, reaching statistical significance (p=0.04). There were no differences in the parameters of fetal well being (Apgar and pH). CONCLUSIONS: The use of therapy with dinoprostone in patients with PROM could be a safe method and more effective than expectant management.
Authors:
Carlos Larrañaga-Azcárate; Gema Campo-Molina; Ana Felicitas Pérez-Rodríguez; Miguel Ezcurdia-Gurpegui
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  87     ISSN:  1600-0412     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2008  
Date Detail:
Created Date:  2008-01-30     Completed Date:  2008-04-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  195-200     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Virgen del Camino Hospital, Pamplona, Spain. clarrana@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Administration, Intravaginal
Adult
Anti-Bacterial Agents / therapeutic use
Cesarean Section / statistics & numerical data
Delayed-Action Preparations / therapeutic use
Dinoprostone / therapeutic use*
Female
Fetal Membranes, Premature Rupture / therapy*
Fever / drug therapy
Humans
Labor Stage, First
Labor, Induced
Linear Models
Oxytocics / therapeutic use*
Oxytocin / therapeutic use
Parity
Pregnancy
Retrospective Studies
Time Factors
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Delayed-Action Preparations; 0/Oxytocics; 363-24-6/Dinoprostone; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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