| Dinitrotoluene structure-dependent initiation of hepatocytes in vivo. | |
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MedLine Citation:
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PMID: 6135515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Technical grade dinitrotoluene (TDNT), composed principally of 2,4-DNT (76%) and 2,6-DNT (20%), is a potent hepatocarcinogen when fed to male F-344 rats for 1 year (100% incidence of hepatocellular carcinoma) while 2,4-DNT is only weakly hepatocarcinogenic. The present investigation was designed to determine the relative initiating potential of DNT isomers compared with the initiating potential of TDNT. A single administration of either TDNT or 2,6-dinitrotoluene (75 mg/kg, p.o.), in combination with partial hepatectomy, initiated hepatocytes in rats when assayed using hepatic initiation-promotion protocols. Five other DNT isomers (2,3; 2,4; 2,5; 3,4, and 3,5-DNT) evaluated similarly exhibited no such potential. Although 2,6-DNT was a relatively weak initiator, its activity was comparable to the initiating activity detected in TDNT. These data begin to provide an explanation for the marked differences in the hepatocarcinogenic potency of TDNT and 2,4-DNT observed in independent 2 year bioassays. |
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Authors:
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T B Leonard; O Lyght; J A Popp |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Carcinogenesis Volume: 4 ISSN: 0143-3334 ISO Abbreviation: Carcinogenesis Publication Date: 1983 Aug |
Date Detail:
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Created Date: 1983-09-23 Completed Date: 1983-09-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1059-61 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acyltransferases
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metabolism Animals Carcinogens / toxicity* Cell Transformation, Neoplastic Dinitrobenzenes / toxicity* Hepatectomy Liver / drug effects, enzymology Liver Neoplasms, Experimental / chemically induced* Liver Regeneration Male Nitrobenzenes / toxicity* Rats Rats, Inbred F344 Transglutaminases |
| Chemical | |
Reg. No./Substance:
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0/Carcinogens; 0/Dinitrobenzenes; 0/Nitrobenzenes; 121-14-2/2,4-dinitrotoluene; 606-20-2/2,6-dinitrotoluene; EC 2.3.-/Acyltransferases; EC 2.3.2.13/Transglutaminases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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