Document Detail

Diminished short-term heart rate variability predicts inducible ventricular tachycardia.
MedLine Citation:
PMID:  9498944     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The purpose of this study is to determine whether short-term heart rate variability (HRV) can be used successfully to predict inducible ventricular tachycardia (VT). METHODS: A high-speed (300 mm/s) electrocardiographic recording was obtained in 32 patients in the supine position prior to programmed ventricular stimulation. Beat-to-beat RR intervals (in milliseconds) were derived from an 11-beat strip (10 RR intervals). Logistic regression was used to study the relationship between several variables and a dichotomous dependent variable (inducible, clinical, or electrocardiographic evidence of VT). RESULTS: Of 32 patients, 12 had inducible VT (inducible VT group) and 20 had no clinical or electrocardiographic evidence of VT (control group). Mean short-term HRV values were significantly lower in those with inducible VT than in the control group in all patients (25+/-15 ms, n=12 vs 67+/-22 ms, n=20; p<0.0001) and in patients with coronary artery disease or congestive heart failure or both (22+/-13 ms, n=11 vs 63+/-23 ms, n=11; p<0.0001). For the group as a whole, short-term HRV was < or =50 ms in 11 of 12 patients (92%) with inducible VT, but was < or =50 ms in only 3 of 20 control subjects (15%; p<0.001). As a result of a stepwise selection procedure conducted within the logistic regression, only the short-term HRV was found to be predictive of inducible VT (p<0.0001). CONCLUSION: Short-term HRV is significantly lower in subjects with inducible VT than in those without clinical or electrocardiographic evidence of VT. The probability of developing sudden death increases substantially when short-term HRV decreases below 50 ms.
M Bikkina; M A Alpert; R Mukerji; M Mulekar; B Y Cheng; V Mukerji
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Chest     Volume:  113     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-10     Completed Date:  1998-03-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  312-6     Citation Subset:  AIM; IM    
Division of Cardiology, University of South Alabama College of Medicine, Mobile, USA.
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MeSH Terms
Cardiac Pacing, Artificial / methods
Coronary Angiography
Coronary Disease / physiopathology
Electrocardiography / methods
Heart Arrest / physiopathology
Heart Failure / physiopathology
Heart Rate / physiology*
Logistic Models
Middle Aged
Predictive Value of Tests
Sensitivity and Specificity
Stroke Volume
Supine Position
Syncope / physiopathology
Tachycardia, Ventricular / etiology*,  physiopathology
Ventricular Function, Left

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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