Document Detail

Diminished pulse pressure under mental stress characterizes normotensive adolescents with parental high blood pressure.
MedLine Citation:
PMID:  3763788     Owner:  NLM     Status:  MEDLINE    
An exaggerated blood pressure response to mental stress is believed to characterize young adults with genetic risk of essential hypertension, suggesting that stress-induced changes might provide a useful index of pathogenetic processes. We explored this by studying pressor responsivity to competitive tasks in adolescents drawn from a large urban population. Individuals with systolic or diastolic pressures persistently between the 85th and 95th percentiles were evaluated on basal blood pressure, parental history of hypertension, and pressor and heart rate response to a challenging video game. Basal pressure was measured again at 6, 10, and 14 months. A persistently diminished pulse pressure was the cardiovascular characteristic that most reliably typified normotensive subjects with familial hypertension. Response to the video game was the best indicator of risk status. Contrary to expectations derived from research with convenience samples, epidemiologic investigation points to an increased peripheral resistance and lower cardiac output as the cardiovascular pattern more prominently associated with genetic risk in the normotensive adolescent.
C K Ewart; W L Harris; S Zeger; G A Russell
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Psychosomatic medicine     Volume:  48     ISSN:  0033-3174     ISO Abbreviation:  Psychosom Med     Publication Date:    1986 Sep-Oct
Date Detail:
Created Date:  1986-11-14     Completed Date:  1986-11-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  489-501     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Cardiac Output
Heart Rate
Hypertension / genetics*
Stress, Psychological / physiopathology*
Vascular Resistance
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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