| Diminished protein binding capacity of uremic sera for valproate following hemodialysis: role of free fatty acids and uremic compounds. | |
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MedLine Citation:
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PMID: 8739287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We previously reported higher free phenytoin concentration in predialysis serum compared to postdialysis serum. In our present study with valproic acid, we observed an opposite effect, where free valproic acid concentration was higher in postdialysis serum. The increased free valproic acid concentrations in postdialysis sera (15.4-77.4% higher in postdialysis sera) were probably related to a 2-to 4-fold increase in free fatty acid concentrations in postdialysis sera. On the other hand, when an aliquot of predialysis serum pool was subjected to in vitro equilibrium dialysis and then both undialyzed and dialyzed serum pools were supplemented with valproic acid and incubated, the concentration of valproic acid in dialyzed serum was significantly lower than the undialyzed serum. This is probably related to removal of some uremic compounds during in vitro dialysis. Treatment of both pre- and postdialysis sera with activated charcoal corrected the binding deficiency of valproic acid due to removal of both uremic compounds and free fatty acids. |
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Authors:
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A Dasgupta; M Jacques; D Malhotra |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: American journal of nephrology Volume: 16 ISSN: 0250-8095 ISO Abbreviation: Am. J. Nephrol. Publication Date: 1996 |
Date Detail:
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Created Date: 1996-10-09 Completed Date: 1996-10-09 Revised Date: 2007-02-14 |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 327-33 Citation Subset: IM |
Affiliation:
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Department of Pathology, University of New Mexico School of Medicine, Albuquerque, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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blood* Charcoal Creatinine / blood Fatty Acids, Nonesterified / blood* Humans Protein Binding Renal Dialysis* Serum Albumin / metabolism* Urea / blood Uremia / blood*, therapy Valproic Acid / blood* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Fatty Acids, Nonesterified; 0/Serum Albumin; 16291-96-6/Charcoal; 57-13-6/Urea; 60-27-5/Creatinine; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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