Document Detail


Diminished mesenteric vaso- and venoconstriction and elevated plasma ANP and BNP with simulated microgravity.
MedLine Citation:
PMID:  18218919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Diminished constriction of arteries and veins following exposure to microgravity or bed rest is associated with a reduced ability to augment peripheral vascular resistance (PVR) and stroke volume during orthostasis. We tested the hypothesis that small mesenteric arteries and veins, which are not exposed to large pressure shifts during simulated microgravity via head-down tail suspension (HDT), will exhibit decrements in adrenergic constriction after HDT in rats. Small mesenteric arteries and veins from control (Con; n = 41) and HDT (n = 35) male Sprague-Dawley rats were studied in vitro. Vasoactive responsiveness to norepinephrine (NE) in arteries (10(-9) to 10(-4) M) and veins (pressure-diameter responses from 2 to 12 cmH(2)O after incubation in 10(-6) or 10(-4) M NE) were evaluated. Plasma concentrations of atrial (ANP) and NH(2)-terminal prohormone brain (NT-proBNP) natriuretic peptides were also measured. In mesenteric arteries, sensitivity and maximal responsiveness to NE were reduced with HDT. In mesenteric veins there was a diminished venoconstriction to NE at any given pressure in HDT. Plasma concentrations of both ANP and NT-proBNP were increased with HDT, and maximal arterial and venous constrictor responses to NE after incubation with 10(-7) M ANP or brain natriuretic peptide (BNP) were diminished. These data demonstrate that, in a vascular bed not subjected to large hydrodynamic differences with HDT, both small arteries and veins have a reduced responsiveness to adrenergic stimulation. Elevated levels of circulating ANP or NT-proBNP could adversely affect the ability of these vascular beds to constrict in vivo and conceivably could alter the intrinsic constrictor properties of these vessels with long-term exposure.
Authors:
Bradley J Behnke; David C Zawieja; Anatoliy A Gashev; Chester A Ray; Michael D Delp
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-01-24
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  104     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-02     Completed Date:  2008-06-17     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1273-80     Citation Subset:  IM    
Affiliation:
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA. mdelp@ufl.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Natriuretic Factor / blood*
Body Weight / physiology
Capillaries / physiology
Head-Down Tilt
Male
Mesenteric Arteries / drug effects,  physiology
Mesenteric Veins / drug effects,  physiology
Muscle, Smooth, Vascular / physiology
Natriuretic Peptide, Brain / blood*
Norepinephrine / pharmacology
Organ Size / physiology
Rats
Rats, Sprague-Dawley
Splanchnic Circulation / physiology*
Stimulation, Chemical
Sympathetic Nervous System / physiology
Vascular Resistance / physiology
Vasoconstriction / physiology*
Vasoconstrictor Agents / pharmacology
Weightlessness Simulation*
Grant Support
ID/Acronym/Agency:
DC 006459/DC/NIDCD NIH HHS; F32 AG 25622/AG/NIA NIH HHS; HL 58503/HL/NHLBI NIH HHS; P01 HL 077670/HL/NHLBI NIH HHS; P01 HL077670/HL/NHLBI NIH HHS; R01 DC006459/DC/NIDCD NIH HHS; R01 HL075199-04/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 114471-18-0/Natriuretic Peptide, Brain; 51-41-2/Norepinephrine; 85637-73-6/Atrial Natriuretic Factor
Comments/Corrections
Comment In:
J Appl Physiol (1985). 2008 May;104(5):1257-8   [PMID:  18276902 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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