| Diminished hypoxic ventilatory responses in near-miss sudden infant death syndrome. | |
| | |
MedLine Citation:
|
PMID: 7263394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The ventilatory response to hypoxia and to hypercarbia was assessed in 36 near-miss sudden infant death syndrome (N.M SIDS) and 23 control infants. Base-line measurements during non-REM sleep documented no significant difference in respiratory frequency, alveolar CO2 and O2 partial pressure (PAco2 and PAo2) or tidal volume between the N-M SIDS and control infants. In the N.M SIDS group, mean inspiratory flow and minute ventilation (VI) were significantly lower than in the control group (p less than 0.001 and p less than 0.01, respectively), and the slope of the ventilatory response to hypercarbia ((delta VI/Torr Paco2) was only 21 +/- 1.9 (SE) ml.kg-1 min-1 Torr PAco2 compared with 62 +/- 3.5 in controls (p less than 0.001). For both groups, the increase in ventilation with hypoxia appeared linear within the PAo2 range assessed (65-115 Torr) and was therefore expressed as the slope of the delta VI/PAo2 plot (ml.kg-1 min-1 per Torr PAo2). The slope of the hypoxic ventilatory response was significantly less in the N-M SIDS than in the control group, -8.3 +/- 1.0 VS. -19.9 +/- 1.5, respectively (p less than 0.001). In summary, in comparison to control infants, N-M SIDS infants as a group have a significantly smaller increase in VI in response to hypoxia as well as to hypercarbia. |
| | |
Authors:
|
C E Hunt; K McCulloch; R T Brouillette |
Related Documents
:
|
2734234 - Assessment of in utero hypoxia and risk of sudden infant death syndrome. 9274944 - Morphology, immunohistochemistry and morphometry of pancreatic islets in cases of sudde... 14693404 - Questionnaire study to japanese sids families. 9672514 - Influence of increased survival in very low birth weight, low birth weight, and normal ... 6708124 - Recent mortality patterns associated with economic development in eastern europe and th... 12042554 - Insulin-like growth factor i and leptin in umbilical cord plasma and infant birth size ... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of applied physiology: respiratory, environmental and exercise physiology Volume: 50 ISSN: 0161-7567 ISO Abbreviation: J Appl Physiol Publication Date: 1981 Jun |
Date Detail:
|
Created Date: 1981-10-25 Completed Date: 1981-10-25 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7801242 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1313-7 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anoxia
/
physiopathology* Arousal / physiology Gastroesophageal Reflux / physiopathology* Humans Infant Lung / physiology Oxygen Respiration* Sleep / physiology Sudden Infant Death / physiopathology* Tidal Volume |
| Grant Support | |
ID/Acronym/Agency:
|
RR-05475-14/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Platelet sequestration in lung with hemorrhagic shock and reinfusion in dogs.
Next Document: Lung compliance and its transient elevations measured with pulse-flow method.