|Diminished expression and function of TLR in lymphatic filariasis: a novel mechanism of immune dysregulation.|
|PMID: 16002719 Owner: NLM Status: MEDLINE|
|Lymphatic filariasis is a disease characterized by immune dysregulation involving APC and T cell populations. To assess the contribution of TLR in mediating this dysregulation, we examined the expression of TLR1, TLR2, TLR4, and TLR9 on B cells and monocytes of filaria-infected and uninfected individuals. Baseline expression of TLR was significantly lower in B cells but not in monocytes of the filaria-infected group compared with the uninfected group. Upon stimulation with filarial Ag, a diminished up-regulation of TLR was observed in both B cells and monocytes of infected individuals. Finally, stimulation of B cells and monocytes with TLR ligands resulted in decreased B cell and monocyte activation/cytokine production, indicating a state of immune tolerance. This dysregulation is associated with diminished CD4(+) T cell production of IFN-gamma and IL-5. The diminished expression and function of TLR is thus a likely consequence of chronic Ag stimulation and could serve as a novel mechanism underlying the dysfunctional immune response in filariasis.|
|Subash Babu; Carla P Blauvelt; V Kumaraswami; Thomas B Nutman|
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|Type: Comparative Study; Journal Article|
|Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 175 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 2005 Jul|
|Created Date: 2005-07-08 Completed Date: 2005-09-27 Revised Date: 2008-11-21|
Medline Journal Info:
|Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States|
|Languages: eng Pagination: 1170-6 Citation Subset: AIM; IM|
|Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Bethesda, MD 20892, USA. firstname.lastname@example.org|
|APA/MLA Format Download EndNote Download BibTex|
Antigens, Helminth / pharmacology
B-Lymphocytes / immunology, metabolism, parasitology
Brugia malayi / immunology
CD4-Positive T-Lymphocytes / immunology, metabolism, parasitology
DNA-Binding Proteins / antagonists & inhibitors, biosynthesis, metabolism
Elephantiasis, Filarial / immunology*, metabolism*, parasitology
Interferon-gamma / antagonists & inhibitors, biosynthesis
Interleukin-5 / antagonists & inhibitors, biosynthesis
Lymphocyte Activation / immunology
Membrane Glycoproteins / antagonists & inhibitors*, biosynthesis*, metabolism, physiology
Monocytes / immunology, metabolism, parasitology
Receptors, Cell Surface / antagonists & inhibitors*, biosynthesis*, metabolism, physiology
Toll-Like Receptor 1
Toll-Like Receptor 2
Toll-Like Receptor 4
Toll-Like Receptor 9
Tuberculin / pharmacology
Wuchereria bancrofti / immunology
|0/Antigens, Helminth; 0/DNA-Binding Proteins; 0/Interleukin-5; 0/Membrane Glycoproteins; 0/Receptors, Cell Surface; 0/TLR2 protein, human; 0/TLR4 protein, human; 0/TLR9 protein, human; 0/Toll-Like Receptor 1; 0/Toll-Like Receptor 2; 0/Toll-Like Receptor 4; 0/Toll-Like Receptor 9; 0/Toll-Like Receptors; 0/Tuberculin; 82115-62-6/Interferon-gamma|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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