| Diminished error-related brain activity as a promising endophenotype for substance-use disorders: evidence from high-risk offspring. | |
| | |
MedLine Citation:
|
PMID: 23145495 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
One of the core features of individuals with a substance-use disorder (SUD) is the reduced ability to successfully process errors and monitor performance, as reflected by diminished error-related negativities (ERN). However, whether these error-related brain abnormalities are caused by chronic substance use or rather predates it remains unclear. The present study elucidated whether hypoactive performance monitoring represents an endophenotypic vulnerability marker for SUD by using a high-risk paradigm. We assessed the behavioral components of error-processing, as well as the amplitude of the ERN in the event-related brain potential (ERP) during performance of the Eriksen Flanker Task among high-risk adolescents of parents with a SUD (HR; n = 28) and normal-risk controls (NR; n = 40). Results revealed that HR offspring were characterized by a higher prevalence of internalizing symptoms and more frequent cannabis use, the latter having a significant influence on the ERN. Interestingly, risk group uniquely predicted the negativity amplitude in response to error trials above and beyond confounding variables. Moreover, we found evidence of smaller ERN amplitudes in (cannabis use-naïve) HR offspring, reflecting impaired early processing of error information and suboptimal performance monitoring, whereas no robust group differences were found for overall behavioral performance. This effect was independent of an overall reduction in brain activity. Taken together, although we cannot rule out alternative explanations, the results of our study may provide evidence for the idea that diminished error-processing represents a promising endophenotype for SUD that may indicate a vulnerability to the disorder. |
| | |
Authors:
|
Anja S Euser; Brittany E Evans; Kirstin Greaves-Lord; Anja C Huizink; Ingmar H A Franken |
Related Documents
:
|
23283025 - Sitting and watching the others being active: the experienced difficulties in pe when h... 10959525 - Fear conditioning and brain activity: a positron emission tomography study in humans. 17346905 - Neural-network simulations of two context-dependence phenomena. 23103305 - Acute lorazepam effects on neurocognitive performance. 7789205 - The organization of reactivated memory in infancy. 6137495 - The effect of coping statements on progress through a desensitization hierarchy. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-12 |
Journal Detail:
|
Title: Addiction biology Volume: - ISSN: 1369-1600 ISO Abbreviation: Addict Biol Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9604935 Medline TA: Addict Biol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction. |
Affiliation:
|
Institute of Psychology, Erasmus University Rotterdam, The Netherlands; Department of Child and Adolescent Psychiatry, Erasmus Medical Center Rotterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Solar UV Exposure at Eye Is Different from Environmental UV: Diurnal Monitoring at Different Rotatio...
Next Document: Aetiology and outcome of open and closed globe eye injuries in children.