| Diminished coronary flow velocity reserve and aortic distensibility in elderly patients with chest pain and negative coronary angiograms. | |
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MedLine Citation:
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PMID: 18852541 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Aging is a dominant process that alters vascular stiffness, endothelial function and coronary flow regulation. The objective of our work was to assess simultaneously the elastic properties of the descending aorta and coronary flow velocity reserve (CFR) during the same transesophageal echocardiography (TEE) in elderly patients. METHODS: The following patients with normal epicardial coronary arteries were compared: 30 subjects under 55 years of age (group 1) and 17 patients over 55 years (group 2). A complete TEE examination was carried out in all patients, and the following aortic elastic properties were calculated from aortic diameter and blood pressure data: aortic elastic modulus [E(p)] and Young's circumferential static elastic modulus [E(s)]. Doppler evaluation of left anterior descending coronary flow velocity was performed in resting conditions and after administration of 0.56 mg/Kg dipyridamole over 4 min. Peak coronary flow velocities were measured at the 6th minute at maximum vasodilation. CFR was estimated as the ratio of hyperemic to basal peak diastolic coronary flow velocities. RESULTS: Peak hyperemic diastolic coronary flow velocities were significantly decreased (139.1+/-35.6 cm/s vs 105.7+/-39.7 cm/s, p<0.01) in patients >55 years. CFR was decreased (2.67+/-1.05 vs 2.13+/-0.56, p<0.05), whereas E(p) (in 103 mmHg, 0.59+/-0.49 vs 0.94+/-0.65, p<0.05) and E(s) (in 103 mmHg, 5.70+/-4.30 vs 8.47+/-5.14, p<0.05) were increased in patients >55 years. A correlation was found between CFR and E(p) (r=-0.20, p<0.05). CONCLUSIONS: CFR and aortic distensibility are altered in elderly patients. There is a relationship between these functional parameters. |
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Authors:
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Attila Nemes; Tamás Forster; Miklós Csanády |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Aging clinical and experimental research Volume: 20 ISSN: 1594-0667 ISO Abbreviation: Aging Clin Exp Res Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-10-14 Completed Date: 2008-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101132995 Medline TA: Aging Clin Exp Res Country: Italy |
Other Details:
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Languages: eng Pagination: 297-301 Citation Subset: IM |
Affiliation:
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Second Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary. nemes@in2nd.szote.u-szeged.hu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aorta* Blood Flow Velocity Chest Pain / physiopathology* Coronary Angiography Female Humans Male Middle Aged Regional Blood Flow* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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