Document Detail

Diminished albumin binding of zinc in serum of pregnant women.
MedLine Citation:
PMID:  1070419     Owner:  NLM     Status:  MEDLINE    
1. Distribution of zinc between the metalloprotein alpha 2-macroglobulin and albumin was determined in samples of serum obtained from twenty-three women in their third trimester of pregnancy and eighteen women who were not pregnant. 2. The decrease observed in total serum zinc in the group of pregnant women could be accounted for in large part by a decreased concentration of albumin-bound zinc. 3. The concentration of serum albumin was lower in the pregnant women, thus hypoalbuminaemia, which is often invoked to explain hypozincaemia in pathological situations, may in part account for hypozincaemia in pregnancy. 4. The affinity of albumin for zinc added to serum from pregnant women was less than that of albumin from non-pregnant women. This was determined by competition experiments between albumin and glycine for zinc. Decreased affinity of serum albumin for zinc may also contribute to the hypozincaemia associated with pregnancy.
E Giroux; P J Schechter; J Schoun
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science and molecular medicine     Volume:  51     ISSN:  0301-0538     ISO Abbreviation:  Clin Sci Mol Med     Publication Date:  1976 Dec 
Date Detail:
Created Date:  1977-03-15     Completed Date:  1977-03-15     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0367540     Medline TA:  Clin Sci Mol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  545-9     Citation Subset:  IM    
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MeSH Terms
Metalloproteins / blood
Protein Binding
Serum Albumin / metabolism
Zinc / blood*
Reg. No./Substance:
0/Ligands; 0/Macroglobulins; 0/Metalloproteins; 0/Serum Albumin; J41CSQ7QDS/Zinc

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