| Diminished activity of ceftizoxime in comparison to cefotaxime and ceftriaxone against Streptococcus pneumoniae. | |
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MedLine Citation:
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PMID: 7756494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous reports documenting the essentially identical spectra of activity of ceftizoxime, cefotaxime, and ceftriaxone prompted our hospital formulary committee to replace the latter two drugs with ceftizoxime on the basis of cost differences. However, we subsequently observed that every one of 60 isolates of Streptococcus pneumoniae tested was less susceptible to ceftizoxime than to either cefotaxime or ceftriaxone. The difference between minimal inhibitory concentrations (MICs) was greatest for strains moderately or fully resistant to penicillin, which at our institution represent approximately 32% of all isolates of S. pneumoniae. Ten isolates with cefotaxime and ceftriaxone MICs of 2.0-6.0 micrograms/mL had ceftizoxime MICs of > or = 256 micrograms/mL. Time-kill kinetic studies assessing bactericidal activity confirmed the diminished activity of ceftizoxime against penicillin-resistant isolates of S. pneumoniae. Ceftizoxime should not be used to treat proven or suspected pneumococcal infection in areas where resistance to penicillin is prevalent. |
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Authors:
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D W Haas; C W Stratton; J P Griffin; L Weeks; S C Alls |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Volume: 20 ISSN: 1058-4838 ISO Abbreviation: Clin. Infect. Dis. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-06-29 Completed Date: 1995-06-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9203213 Medline TA: Clin Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 671-6 Citation Subset: IM |
Affiliation:
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Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-4751, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ceftizoxime
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pharmacology* Ceftriaxone / pharmacology* Microbial Sensitivity Tests Penicillin Resistance Streptococcus pneumoniae / drug effects* Time Factors |
| Chemical | |
Reg. No./Substance:
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68401-81-0/Ceftizoxime; 73384-59-5/Ceftriaxone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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