| Diminished cardiac fibrosis in heart failure is associated with altered ventricular arrhythmia phenotype. | |
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MedLine Citation:
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PMID: 20233273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to define the role of interstitial fibrosis in the proarrhythmic phenotype of failing ventricular myocardium. BACKGROUND: Multiple cellular events that occur during pathological remodeling of the failing ventricle are implicated in the genesis of ventricular tachycardia (VT), including interstitial fibrosis. Recent studies suggest that ventricular fibrosis is reversible, and current anti-remodeling therapies attenuate ventricular fibrosis. However, the role of interstitial fibrosis in the proarrhythmic phenotype of failing ventricular myocardium is currently not well defined. METHODS: Class II histone deacetylases (HDACs) have been implicated in promoting collagen biosynthesis. As these enzymes are inhibited by protein kinase D1 (PKD1), we studied mice with cardiomyocyte-specific transgenic over-expression of a constitutively active mutant of PKD1 (caPKD). caPKD mice were compared with animals in which cardiomyopathy was induced by severe thoracic aortic banding (sTAB). Hearts were analyzed by echocardiographic and electrocardiographic means. Interstitial fibrosis was assessed by histology and quantified biochemically. Ventricular arrhythmias were induced by closed-chest, intracardiac pacing. RESULTS: Similar degrees of hypertrophic growth, systolic dysfunction and mortality were observed in the two models. In sTAB mice, robust ventricular fibrosis was readily detected, but myocardial collagen content was significantly reduced in caPKD mice. As expected, VT was readily inducible by programmed stimulation in sTAB mice and VT was less inducible in caPKD mice. Surprisingly, episodes of VT manifested longer cycle lengths and longer duration in caPKD mice. CONCLUSION: Attenuated ventricular fibrosis is associated with reduced VT inducibility, increased VT duration, and significantly longer arrhythmia cycle length. |
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Authors:
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Jorge Massare; Jeff M Berry; Xiang Luo; Farhana Rob; Janet L Johnstone; John M Shelton; Rhonda Bassel-Duby; Joseph A Hill; R Haris Naseem |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular electrophysiology Volume: 21 ISSN: 1540-8167 ISO Abbreviation: J. Cardiovasc. Electrophysiol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-11-05 Completed Date: 2011-02-18 Revised Date: 2013-03-14 |
Medline Journal Info:
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Nlm Unique ID: 9010756 Medline TA: J Cardiovasc Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 1031-7 Citation Subset: IM |
Copyright Information:
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© 2010 Wiley Periodicals, Inc. |
Affiliation:
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Department of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, Texas 75390-8573, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Animals Cardiomyopathy, Dilated / complications*, enzymology, pathology, physiopathology Disease Models, Animal Electrophysiologic Techniques, Cardiac Fibrosis Genotype Heart Failure / enzymology, etiology*, pathology, physiopathology Male Mice Mice, Inbred C57BL Mice, Transgenic Mutation Myocardium / enzymology, pathology* Phenotype Protein Kinase C / genetics, metabolism Tachycardia, Ventricular / enzymology, etiology*, genetics, pathology, physiopathology, prevention & control Up-Regulation Ventricular Remodeling* |
| Grant Support | |
ID/Acronym/Agency:
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HL-006296/HL/NHLBI NIH HHS; HL-075173/HL/NHLBI NIH HHS; HL-080144/HL/NHLBI NIH HHS; R01 HL075173/HL/NHLBI NIH HHS; R01 HL080144/HL/NHLBI NIH HHS; R01 HL090842/HL/NHLBI NIH HHS; T32 HL007360/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.7.10.-/protein kinase D; EC 2.7.11.13/Protein Kinase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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