| Dimethylsulfoxide with heparin in the treatment of smoke inhalation injury. | |
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MedLine Citation:
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PMID: 3356738 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent studies suggest that lung lesions occurring in inhalation injury result from actions of oxygen-free radicals released from polymorphonuclear leukocytes marginating in the pulmonary microcirculation and tracheobronchial region. Peroxide and hydroxyl ions have been implicated as mediators in the increased microvascular permeability and pulmonary edema noted after inhalation injury. In this study we evaluated the use of an O2-free radical scavenger, dimethylsulfoxide (DMSO), and heparin in the treatment of smoke inhalation. Ewes (N = 26) that had been surgically prepared five days earlier were insufflated with smoke from burning cotton. There were four groups: controls (n = 7), DMSO (n = 6), heparin (n = 6), and DMSO plus heparin (n = 7). All animals were given ventilatory support to maintain their PO2 above 60 mmHg and their PCO2 below 45 mmHg. There was a significant difference in survival rates between groups. By 72 hours all seven of the control group were dead. All animals in the DMSO plus heparin group survived, four of the DMSO group died, and two of the heparin group died. Lung lymph flow was not as high in the DMSO plus heparin group as in the heparin-only group. DMSO was proved effective in reducing the lung injury associated with smoke inhalation. |
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Authors:
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M Brown; M Desai; L D Traber; D N Herndon; D L Traber |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of burn care & rehabilitation Volume: 9 ISSN: 0273-8481 ISO Abbreviation: J Burn Care Rehabil Publication Date: 1988 Jan-Feb |
Date Detail:
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Created Date: 1988-05-16 Completed Date: 1988-05-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110188 Medline TA: J Burn Care Rehabil Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 22-5 Citation Subset: IM |
Affiliation:
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University of Texas Medical Branch, Galveston. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Burns, Inhalation / drug therapy*, mortality Capillary Permeability Dimethyl Sulfoxide / therapeutic use* Female Free Radicals Heparin / therapeutic use* Sheep |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 67-68-5/Dimethyl Sulfoxide; 9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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