Document Detail

Dimethylsulfoxide with heparin in the treatment of smoke inhalation injury.
MedLine Citation:
PMID:  3356738     Owner:  NLM     Status:  MEDLINE    
Recent studies suggest that lung lesions occurring in inhalation injury result from actions of oxygen-free radicals released from polymorphonuclear leukocytes marginating in the pulmonary microcirculation and tracheobronchial region. Peroxide and hydroxyl ions have been implicated as mediators in the increased microvascular permeability and pulmonary edema noted after inhalation injury. In this study we evaluated the use of an O2-free radical scavenger, dimethylsulfoxide (DMSO), and heparin in the treatment of smoke inhalation. Ewes (N = 26) that had been surgically prepared five days earlier were insufflated with smoke from burning cotton. There were four groups: controls (n = 7), DMSO (n = 6), heparin (n = 6), and DMSO plus heparin (n = 7). All animals were given ventilatory support to maintain their PO2 above 60 mmHg and their PCO2 below 45 mmHg. There was a significant difference in survival rates between groups. By 72 hours all seven of the control group were dead. All animals in the DMSO plus heparin group survived, four of the DMSO group died, and two of the heparin group died. Lung lymph flow was not as high in the DMSO plus heparin group as in the heparin-only group. DMSO was proved effective in reducing the lung injury associated with smoke inhalation.
M Brown; M Desai; L D Traber; D N Herndon; D L Traber
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of burn care & rehabilitation     Volume:  9     ISSN:  0273-8481     ISO Abbreviation:  J Burn Care Rehabil     Publication Date:    1988 Jan-Feb
Date Detail:
Created Date:  1988-05-16     Completed Date:  1988-05-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8110188     Medline TA:  J Burn Care Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  22-5     Citation Subset:  IM    
University of Texas Medical Branch, Galveston.
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MeSH Terms
Burns, Inhalation / drug therapy*,  mortality
Capillary Permeability
Dimethyl Sulfoxide / therapeutic use*
Free Radicals
Heparin / therapeutic use*
Reg. No./Substance:
0/Free Radicals; 67-68-5/Dimethyl Sulfoxide; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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