Document Detail

Dimethylarsinous acid disturbs cytokinesis.
MedLine Citation:
PMID:  19319459     Owner:  NLM     Status:  MEDLINE    
Dimethylarsinous acid (DMAIII) induced tetraploidy and multinucleation in V79 cells. While the highest yield of tetraploids and multinucleated cells was at 1.25 microM of DMAIII, the mitotic index was highest at DMAIII 2.5 microM due to mitotic arrest. Mitosis was not observed at 5 microM. We observed V79 cells treated with DMAIII and visualized with rhodamine-phalloidin. Abnormal actin location was observed in the dividing cells which were treated with DMAIII and visualized with rhodamine-phalloidin. These findings suggested strongly that DMAIII inhibits not only formation of the normal mitotic spindle but cytokinesis and induces the formation of multinuclear cells.
Mari Kitamura; Koichi Kuroda; Ginji Endo
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Publication Detail:
Type:  Journal Article     Date:  2009-03-25
Journal Detail:
Title:  Bulletin of environmental contamination and toxicology     Volume:  83     ISSN:  1432-0800     ISO Abbreviation:  Bull Environ Contam Toxicol     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-04     Completed Date:  2009-07-10     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0046021     Medline TA:  Bull Environ Contam Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15-8     Citation Subset:  IM    
Department of Food Science and Nutrition, School of Human Environmental Science, Mukogawa Women's University, 6-46 Ikebiraki-cho, Nishinomiya, Japan.
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MeSH Terms
Cacodylic Acid / analogs & derivatives*,  toxicity
Cell Division / drug effects
Cell Line
Cytokinesis / drug effects*
Reg. No./Substance:
0/dimethylarsinous acid; 75-60-5/Cacodylic Acid

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