| Dimethyl titanocene Y: a valuable precursor for libraries of cytotoxic titanocene derivatives. | |
| | |
MedLine Citation:
|
PMID: 20452674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Reaction of the known titanocene Y 2 with methyl lithium at -15 degrees C yields bis-[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dimethyl (dimethyl titanocene Y, 3), a hitherto unknown, surprisingly robust titanium (IV) dimethyl species. Dimethyl titanocene Y was utilized in the preparation of several bis-[(p-methoxybenzyl)cyclopentadienyl]titanium(IV) dicarboxylates by the reaction with the free carboxylic acids in fair to good yields. Cytotoxicity of all new compounds has been estimated in Hela S3 cells. |
| | |
Authors:
|
Timo A Immel; Josefine T Martin; Christoph J Dürr; Ulrich Groth; Thomas Huhn |
Related Documents
:
|
17512744 - Inhibition of colon cancer cell growth and antioxidant activity of bioactive compounds ... 1670504 - Synthesis and cytotoxic activity of (e)-1-(2-nitrovinyl) and 1-[n-(tert-butylformiminyl... 836504 - Synthesis and structure-activity relationship studies of cytotoxic epoxide derivatives ... 16006014 - Synthesis and biological activity of alpha-bromoacryloyl lexitropsin conjugates. 2163614 - Comparison of lignin peroxidase, horseradish peroxidase and laccase in the oxidation of... 19533714 - New structural variants of homoserine lactones in bacteria. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-24 |
Journal Detail:
|
Title: Journal of inorganic biochemistry Volume: 104 ISSN: 1873-3344 ISO Abbreviation: J. Inorg. Biochem. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-06-11 Completed Date: 2010-09-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7905788 Medline TA: J Inorg Biochem Country: United States |
Other Details:
|
Languages: eng Pagination: 863-7 Citation Subset: IM |
Copyright Information:
|
(c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Universitätsstrasse 10, Fach 720, 78457 Konstanz, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antibiotics, Antineoplastic*
/
chemical synthesis,
chemistry,
pharmacology Drug Screening Assays, Antitumor / methods Hela Cells Humans Organometallic Compounds* / chemical synthesis, chemistry, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Antibiotics, Antineoplastic; 0/Organometallic Compounds; 0/dimethyl titanocene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Air pollution and hospitalization for epilepsy in Chile.
Next Document: Aberrant regulation of endogenous ouabain-like factor in bipolar subjects.