Document Detail


Dimethyl sulfoxide: recent pharmacological and toxicological research.
MedLine Citation:
PMID:  11474739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A survey of the literature published in the past 2 decades on the basic pharmacology, therapeutic uses and toxicity of dimethyl sulfoxide (DMSO) is presented. A salient pharmacological action of DMSO is its ability to scavenge oxygen-free radicals implicated in xenobiotic-induced tissue damages when given before, during or several hours after the tissue insult. More trials with DMSO in diseases and conditions caused by oxygen-free radicals are warranted.
Authors:
B H Ali
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Veterinary and human toxicology     Volume:  43     ISSN:  0145-6296     ISO Abbreviation:  Vet Hum Toxicol     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-27     Completed Date:  2001-12-07     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7704194     Medline TA:  Vet Hum Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  228-31     Citation Subset:  IM    
Affiliation:
Department of Veterinary Medicine, King Saud University, Buraydah, Saudi Arabia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dimethyl Sulfoxide* / pharmacokinetics,  therapeutic use,  toxicity
Free Radical Scavengers* / pharmacokinetics,  therapeutic use,  toxicity
Humans
Lethal Dose 50
Rats
Chemical
Reg. No./Substance:
0/Free Radical Scavengers; 67-68-5/Dimethyl Sulfoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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