| Dimethoate-induced oxidative damage in erythrocytes of female adult rats: possible protective effect of vitamin E and selenium supplemented to diet. | |
| | |
MedLine Citation:
|
PMID: 21976143 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Pesticide hazards have been accentuated by the sharp rise in their agricultural, industrial and domestic use. Acute exposure to pesticides can cause oxidative damage. Our study investigated the potential ability of selenium (Se) and/or vitamin E, used as nutritional supplements, to alleviate erythrocyte oxidative damage induced by dimethoate (DM), an organophosphate pesticide. Female Wistar rats were exposed to DM (0.2g/L(-1) of drinking water), DM + Se (0.5 mg/kg of diet), DM + vitamin E (100 mg/kg of diet), or DM + Se + vitamin E. Rats exposed to DM for 30 days showed an increase in malondialdehyde levels, superoxide dismutase and glutathione peroxidase activities in their erythocytes, while Na(+),K(+)-ATPase and catalase activities, glutathione, non-protein thiol, vitamin E and vitamin C levels decreased. We also noted an increase in lactate dehydrogenase activity, marker of haemolysis and a decrease in acetylcholinesterase, the principal mode of organophosphorus action. Co-administration of Se or vitamin E to the diet of DM-treated rats ameliorated the biochemical parameters cited above. But the combined effect of Se and vitamin E was more powerful in antagonizing DM-induced oxidative stress. Therefore, our investigation revealed that both Se and vitamin E were useful elements in preventing DM-induced erythrocytes damage. |
| | |
Authors:
|
Ibtissem Ben Amara; Nejla Soudani; Ahmed Hakim; Hanen Bouaziz; Afef Troudi; Khaled Zeghal; Najiba Zeghal |
Related Documents
:
|
1334653 - Fish oil and oat bran in combination effectively lower plasma cholesterol in the rat. 8399103 - Prevention of coprophagy does not alter the hypocholesterolaemic effects of oat bran in... 17299483 - Consumption of an n-3 polyunsaturated fatty acid-enriched dip modulates plasma lipid pr... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-5 |
Journal Detail:
|
Title: Toxicology and industrial health Volume: - ISSN: 1477-0393 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8602702 Medline TA: Toxicol Ind Health Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Animal Physiology Laboratory, Sfax Faculty of Science, University of Sfax, Sfax, Tunisia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of dimethylsulfoxide on behavior and antioxidant enzymes response of planarian Dugesia japon...
Next Document: A systems biology approach to identify molecular pathways altered by HDAC inhibition in osteosarcoma...