| Dimers from dechlorinated rebeccamycin: synthesis, interaction with DNA, and antiproliferative activities. | |
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MedLine Citation:
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PMID: 12008058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the course of structure-activity relationships on rebeccamycin analogues, two dimers of dechlorinated rebeccamycin were synthesised with the aim to improve the interaction with DNA and in vitro antiproliferative activities. The synthesis of two dimeric compounds obtained by joining two molecules of dechlorinated rebeccamycin via the imide nitrogen is described. Melting temperature and DNase I footprinting studies were performed to investigate their interaction with DNA. Four tumour cell lines, murine L1210 leukaemia, human HT29 colon carcinoma, A549 non-small cell lung carcinoma and K-562 leukaemia, were used to evaluate the cytotoxicity of the drugs. Their effects on the cell cycle of L1210 cells were also investigated. |
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Authors:
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Christelle Marminon; Michaël Facompré; Christian Bailly; John Hickman; Alain Pierré; Bruno Pfeiffer; Pierre Renard; Michelle Prudhomme |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of medicinal chemistry Volume: 37 ISSN: 0223-5234 ISO Abbreviation: Eur J Med Chem Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-14 Completed Date: 2003-01-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0420510 Medline TA: Eur J Med Chem Country: France |
Other Details:
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Languages: eng Pagination: 435-40 Citation Subset: IM |
Affiliation:
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Université Blaise Pascal, Synthèse et Etude de Systèmes à Intérêt Biologique, UMR 6504 du CNRS, F-63177 Aubière, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aminoglycosides* Anti-Bacterial Agents / chemical synthesis*, chemistry, pharmacology Carbazoles* Cell Division / drug effects Chlorine / chemistry* DNA / metabolism* DNA Footprinting DNA Topoisomerases, Type I / antagonists & inhibitors Dimerization Humans Indoles* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/Carbazoles; 0/Indoles; 7782-50-5/Chlorine; 9007-49-2/DNA; 93908-02-2/rebeccamycin; EC 5.99.1.2/DNA Topoisomerases, Type I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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