Document Detail

Dimeric inhibin A as a fourth marker for Down's syndrome maternal serum screening in native Japanese women.
MedLine Citation:
PMID:  10932977     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was conducted to assess the usefulness of dimeric inhibin A as a fourth marker for Down's syndrome screening in addition to AFP, hCG and uE3 markers for native Japanese women. METHODS: Serum specimens from 367 native Japanese women in the second trimester were assayed for dimeric inhibin A levels. Day specific dimeric inhibin A medians were established for gestational ages 15.0-21.9. Weekly median values for the native Japanese were compared with those of a U.S. population. Selected Japanese specimens from 15 diagnosed Down's syndrome and 3 trisomy 18 cases were also assayed for dimeric inhibin A. RESULTS: Dimeric inhibin A levels did not vary greatly over the gestational age range as expected. Median value comparison showed that native Japanese dimeric inhibin A medians are higher than the U.S. population medians by an average of 7.95%. Native Japanese dimeric inhibin A median values in this study are 1.77 times higher in Down's syndrome cases than in unaffected pregnancies. Trisomy 18 dimeric inhibin A levels show no significant difference from the unaffected pregnancies. CONCLUSIONS: This report shows for the first time that dimeric inhibin A can be informative as a fourth marker for Down's syndrome screening in native Japanese women. We expect the addition of dimeric inhibin A to a triple marker protocol will increase the accuracy of predicted risk for all pregnancies screened and increase the detection rate of Down's syndrome affected pregnancies.
K Yoshida; Y Kuwabara; T Tanaka; T Onda; R Kudo; H Yamamoto; A Sato; K Yanagida; T Okai; M Sakai; Y Takai; H Uemura; K Hoshi; Y Fukada; T Aono; K Maeda; S Ogita; O Ishiko; Y Murata; T Kanzaki; F Myrick; R E Grier
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  26     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-17     Completed Date:  2000-08-17     Revised Date:  2004-11-18    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  171-4     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Juntendo University School of Medicine, Tokyo, Japan.
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MeSH Terms
Biological Markers / blood*
Chorionic Gonadotropin / blood
Chromosomes, Human, Pair 18
Down Syndrome / blood*,  diagnosis*
Estriol / blood
Gestational Age
Inhibins / blood*
Maternal Age
Pregnancy, High-Risk
Prenatal Diagnosis*
alpha-Fetoproteins / analysis
Reg. No./Substance:
0/Biological Markers; 0/Chorionic Gonadotropin; 0/alpha-Fetoproteins; 50-27-1/Estriol; 57285-09-3/Inhibins

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