Document Detail


Dimensions of emotionality in a rat model of innate anxiety.
MedLine Citation:
PMID:  11345967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Emotionality is thought to be multidimensional, with "anxiety" representing one dimension. Dissecting emotional dimensions in animal models is an essential prerequisite for investigating the neurobiological mechanisms that underlie anxiety. The authors used factor analysis to investigate emotional dimensions in normal rats and rats bred for either high or low anxiety-related behavior. Hyperanxious rats were reduced in emotional dimensions in the elevated plus-maze by selection pressure, and a modified hole board test revealed a dissection of their emotionality with precisely defined dimensions. This enabled clear differentiation of "anxiety" from other emotional dimensions including risk assessment behavior and exploration. Factors extracted by analyzing data from a multiple-test battery corresponded to particular test characteristics rather than to emotional dimensions. The approach used might help to develop specific treatment strategies for anxiety disorders.
Authors:
F Ohl; N Toschi; A Wigger; M S Henniger; R Landgraf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Behavioral neuroscience     Volume:  115     ISSN:  0735-7044     ISO Abbreviation:  Behav. Neurosci.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-05-10     Completed Date:  2001-09-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8302411     Medline TA:  Behav Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-36     Citation Subset:  IM    
Affiliation:
Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany. ohl@mpipsykl.mpg.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Anxiety / genetics*
Arousal / genetics
Avoidance Learning
Emotions / physiology*
Instinct*
Male
Motor Activity
Rats
Rats, Wistar
Selection, Genetic
Species Specificity

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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