| Dimensional growth of the rabbit eye. | |
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MedLine Citation:
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PMID: 12169825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The rabbit eye has been used experimentally in research in vision and ophthalmology. However, there is little information about postnatal growth. The purpose of this study was to determine growth patterns of the rabbit globe from birth to young adult status focusing in particular on the fibrous outer tunic of the globe, the sclera. Eyes of both sexes of New Zealand White rabbits were examined on postnatal days 1, 7, 14, 28, 42 and 56. Axial length, equatorial diameter and corneal diameter were measured using a digital caliper. Plastic-embedded tissue was used to quantify scleral thickness and cellular density at anterior, equatorial and posterior sites. Axial length increased 230% between postnatal days 1 and 56. The rate of growth was not linear and revealed two peaks. The first peak occurred between postnatal days 1-7, and the second between days 14-28. Eye opening occurred on days 9-11. Sex differences were seen, with the male eye being larger (p = 0.00001). Surface area measurements of sclera and cornea revealed that the sclera occupies approximately 5/6 of the outer surface of the globe and the cornea 1/6. Scleral thickness increased from day 1 to day 42 (70-155 microm at the equator) while fibroblast density was found to decrease (0.32 to 0.05 cells/microm(2)). The results suggested that eye opening precedes a unique increase in the rate of eye growth and visual processes may be playing a role in modulating the growth pattern between days 14 and 28. |
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Authors:
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A Barathi; M K Thu; R W Beuerman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cells, tissues, organs Volume: 171 ISSN: 1422-6405 ISO Abbreviation: Cells Tissues Organs (Print) Publication Date: 2002 |
Date Detail:
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Created Date: 2002-08-09 Completed Date: 2003-02-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100883360 Medline TA: Cells Tissues Organs Country: Switzerland |
Other Details:
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Languages: eng Pagination: 276-85 Citation Subset: IM |
Copyright Information:
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Copyright 2002 S. Karger AG, Basel |
Affiliation:
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Singapore National Eye Centre, Singapore Eye Research Institute, National University of Singapore, Singapore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aging / physiology Animals Animals, Newborn Cell Count Cornea / cytology, growth & development Female Fibroblasts / cytology Male Organ Size / physiology Rabbits Sclera / cytology, growth & development* Vision, Ocular / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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