Document Detail


Dim light melatonin onset in alcohol-dependent men and women compared with healthy controls.
MedLine Citation:
PMID:  22217099     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sleep disturbances in alcohol-dependent (AD) individuals may persist despite abstinence from alcohol and can influence the course of the disorder. Although the mechanisms of sleep disturbances of AD are not well understood and some evidence suggests dysregulation of circadian rhythms, dim light melatonin onset (DLMO) has not previously been assessed in AD versus healthy control (HC) individuals in a sample that varied by sex and race. The authors assessed 52 AD participants (mean ± SD age: 36.0 ± 11.0 yrs of age, 10 women) who were 3-12 wks since their last drink (abstinence: 57.9 ± 19.3 d) and 19 age- and sex-matched HCs (34.4 ± 10.6 yrs, 5 women). Following a 23:00-06:00 h at-home sleep schedule for at least 5 d and screening/baseline nights in the sleep laboratory, participants underwent a 3-h extension of wakefulness (02:00 h bedtime) during which salivary melatonin samples were collected every 30 min beginning at 19:30 h. The time of DLMO was the primary measure of circadian physiology and was assessed with two commonly used methodologies. There was a slower rate of rise and lower maximal amplitude of the melatonin rhythm in the AD group. DLMO varied by the method used to derive it. Using 3 pg/mL as threshold, no significant differences were found between the AD and HC groups. Using 2 standard deviations above the mean of the first three samples, the DLMO in AD occurred significantly later, 21:02 ± 00:41 h, than in HC, 20:44 ± 00:21 h (t = -2.4, p = .02). Although melatonin in the AD group appears to have a slower rate of rise, using well-established criteria to assess the salivary DLMO did not reveal differences between AD and HC participants. Only when capturing melatonin when it is already rising was DLMO found to be significantly delayed by a mean 18 min in AD participants. Future circadian analyses on alcoholics should account for these methodological caveats.
Authors:
Deirdre A Conroy; Ilana S Hairston; J Todd Arnedt; Robert F Hoffmann; Roseanne Armitage; Kirk J Brower
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Chronobiology international     Volume:  29     ISSN:  1525-6073     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-05     Completed Date:  2012-04-30     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  35-42     Citation Subset:  IM    
Affiliation:
Addiction Research Center, Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA. daconroy@med.umich.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alcohol Drinking
Alcoholism / complications*
Case-Control Studies
Female
Humans
Light
Male
Melatonin / biosynthesis*
Middle Aged
Questionnaires
Research Design
Sleep
Sleep Disorders / complications*
Sleep Initiation and Maintenance Disorders / complications
Time Factors
Grant Support
ID/Acronym/Agency:
K24 AA000304/AA/NIAAA NIH HHS; K24 AA00304/AA/NIAAA NIH HHS; R01 AA016117/AA/NIAAA NIH HHS; R01 AA016117/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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