Document Detail


Dim light at night increases immune function in Nile grass rats, a diurnal rodent.
MedLine Citation:
PMID:  22217098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With the widespread adoption of electrical lighting during the 20th century, human and nonhuman animals became exposed to high levels of light at night for the first time in evolutionary history. This divergence from the natural environment may have significant implications for certain ecological niches because of the important influence light exerts on the circadian system. For example, circadian disruption and nighttime light exposure are linked to changes in immune function. The majority of studies investigating the effects of light exposure and circadian disruption on the immune system use nocturnal rodents. In diurnal species, many hormones and immune parameters vary with secretion patterns 180° out of phase to those of nocturnal rodents. Thus, the authors investigated the effects of nighttime light exposure on immunocompetence in diurnal Nile grass rats (Arvicanthis niloticus). Rats were housed in either standard 14-h light (L):10-h dark (D) cycles with L ∼150 lux and D 0 lux or dim light at night (dLAN) cycles of LD 14:10 with L ∼150 lux and D 5 lux for 3 wks, then tested for plasma bactericidal capacity, as well as humoral and cell-mediated immune responses. Rats exposed to dLAN showed increased delayed-type hypersensitivity pinna swelling, which is consistent with enhanced cell-mediated immune function. dLAN rats similarly showed increased antibody production following inoculation with keyhole lymphocyte hemocyanin (KLH) and increased bactericidal capacity. Daytime corticosterone concentrations were elevated in grass rats exposed to nighttime dim light, which may have influenced immunological measures. Overall, these results indicate nighttime light affects immune parameters in a diurnal rodent.
Authors:
Laura K Fonken; Achikam Haim; Randy J Nelson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Chronobiology international     Volume:  29     ISSN:  1525-6073     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-05     Completed Date:  2012-04-30     Revised Date:  2013-11-14    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  26-34     Citation Subset:  IM    
Affiliation:
Department of Neuroscience and Institute for Behavioral Medicine Research, The Ohio State University, Columbus, Ohio 43210, USA. fonken.1@osu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Clocks / physiology*
Circadian Rhythm / physiology*
Corticosterone / blood
Enzyme-Linked Immunosorbent Assay / methods
Hemocyanin / metabolism
Immune System
Light
Male
Melatonin / metabolism
Photoperiod
Radioimmunoassay / methods
Rats
Time Factors
Chemical
Reg. No./Substance:
50-22-6/Corticosterone; 73-31-4/Melatonin; 9013-72-3/Hemocyanin; FV4Y0JO2CX/keyhole-limpet hemocyanin
Comments/Corrections
Erratum In:
Chronobiol Int. 2012 May;29(4):530

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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