Document Detail

Diltiazem for treatment of essential hypertension: a double-blind controlled study with reserpine.
MedLine Citation:
PMID:  6391669     Owner:  NLM     Status:  MEDLINE    
In a double-blind, parallel, 12-week trial, antihypertensive effects of diltiazem and reserpine were compared in 107 patients with essential hypertension. Diltiazem reduced blood pressure from 176/100 mmHg to 154/86 mmHg after 12 weeks, and reserpine reduced blood pressure from 171/96 mmHg to 155/85 mmHg. The difference between diltiazem and reserpine was not statistically significant. However, among a subset of patients given 180 mg/day of diltiazem, a significantly better antihypertensive effect was achieved than among a subset given 0.3 mg of reserpine. The incidence of side effects and complications in the diltiazem group was about one half that in the reserpine group (12.3% and 27.1%, respectively). Side effects of diltiazem were mild, and the drug was extremely well tolerated. These results show that diltiazem is an effective antihypertensive drug for the treatment of mild to moderate essential hypertension.
K Ogawa; M Ban; T Ito; T Watanabe; T Kobayashi; N Yamazaki; Y Suzuki
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical therapeutics     Volume:  6     ISSN:  0149-2918     ISO Abbreviation:  Clin Ther     Publication Date:  1984  
Date Detail:
Created Date:  1985-02-21     Completed Date:  1985-02-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7706726     Medline TA:  Clin Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  844-53     Citation Subset:  IM    
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MeSH Terms
Benzazepines / therapeutic use*
Clinical Trials as Topic
Diltiazem / adverse effects,  therapeutic use*
Double-Blind Method
Hypertension / drug therapy*
Middle Aged
Pulse / drug effects
Reserpine / therapeutic use*
Reg. No./Substance:
0/Benzazepines; 42399-41-7/Diltiazem; 50-55-5/Reserpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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