Document Detail

Diltiazem: dose it affect vasospasm?
MedLine Citation:
PMID:  3523805     Owner:  NLM     Status:  MEDLINE    
Calcium antagonists are being investigated for their role in preventing or ameliorating the vasospasm associated with subarachnoid hemorrhage. We have done a phase I and phase II type trial of diltiazem. No effect on spasm was documented. A tendency to increase the bleeding time was noted, but no detrimental clinical effect occurred. The rebleed rate was not changed. It appears that further study of diltiazem through a proper randomized study would not be cost- or time-effective.
F W Saunders; W J Marshall
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Surgical neurology     Volume:  26     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-08-08     Completed Date:  1986-08-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  155-8     Citation Subset:  IM    
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MeSH Terms
Benzazepines / therapeutic use*
Clinical Trials as Topic
Diltiazem / therapeutic use*
Ischemic Attack, Transient / drug therapy*
Random Allocation
Subarachnoid Hemorrhage / drug therapy
Reg. No./Substance:
0/Benzazepines; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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