| Diltiazem counteracts digitalis-dependent splanchnic vasoconstriction in man. | |
| | |
MedLine Citation:
|
PMID: 3429059 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We investigated the vasodilating effect of diltiazem on basal as well as digoxin-dependent splanchnic and systemic hemodynamics in 12 normotensive men, using the hepatic venous catheter technique, the thermodilution method and systolic time intervals. After baseline measurements, diltiazem was administered by a primed-constant infusion (2.5 micrograms/kg/min) in 6 out of 12 subjects. Following an equilibration period of diltiazem infusion, 1 mg digoxin was infused concomitantly over 15 min and hemodynamic changes were determined over 105 min. Control trials with digoxin and concomitant saline infusion were also performed in 7 out of 12 subjects. Diltiazem medication alone lowered only systolic blood pressure without affecting splanchnic hemodynamics. Digoxin without comedication provoked an increase in systolic blood pressure, a decrease in heart rate, mean pulmonary artery pressure and total electromechanical systole (positive inotropic effect), and significantly reduced splanchnic blood flow and increased splanchnic vascular resistance. During concomitant diltiazem infusion, digoxin did not alter splanchnic hemodynamics while the shortening of total electromechanical systole remained unchanged. We conclude, that diltiazem attenuates digoxin-induced splanchnic vasoconstriction and therefore, might be useful in the treatment of digitalis-dependent splanchnic vascular insufficiency. |
| | |
Authors:
|
S Gasic; A Korn; H G Eichler |
Related Documents
:
|
20150209 - Intraoperative vital and haemodynamic monitoring using an integrated multiple-channel m... 10806799 - An experimental study on the disorders of hepatic hemodynamics and changes of plasma hi... 9918919 - Hypoxic hepatitis caused by acute exacerbation of chronic respiratory failure: a case-c... 2716179 - Analysis of acute and chronic heart failure in view of hepatic oxygen supply-demand rel... 7778169 - Arginase release following liver reperfusion. evidence of hemodynamic action of arginas... 7784699 - Effect of prior portosystemic shunt on early hepatic hemodynamics and sinusoids followi... 1093429 - Positive end-expiratory pressure. effect on arterial oxygenation during respiratory fai... 6702689 - Doppler echocardiographic prediction of pulmonary arterial hypertension in congenital h... 1186119 - Unilateral renovascular hypertension in rats. measurements of medullary granules, juxta... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of clinical pharmacology, therapy, and toxicology Volume: 25 ISSN: 0174-4879 ISO Abbreviation: Int J Clin Pharmacol Ther Toxicol Publication Date: 1987 Oct |
Date Detail:
|
Created Date: 1988-03-03 Completed Date: 1988-03-03 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8003415 Medline TA: Int J Clin Pharmacol Ther Toxicol Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 553-7 Citation Subset: IM |
Affiliation:
|
First Medical University Clinic, Division of Clinical Pharmacology, Vienna, Austria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Pressure / drug effects Cardiac Output / drug effects Digoxin / blood, pharmacology* Diltiazem / blood, pharmacology* Heart Rate / drug effects Humans Infusions, Intravenous Liver / blood supply*, drug effects Male Splanchnic Circulation / drug effects* Vascular Resistance / drug effects Vasoconstriction / drug effects* |
| Chemical | |
Reg. No./Substance:
|
20830-75-5/Digoxin; 42399-41-7/Diltiazem |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum protein binding of phenytoin, diazepam and propranolol in chronic renal diseases.
Next Document: The relationship between calcium antagonist-induced hypotension and central monoaminergic system in ...