Document Detail


Dilation-dependent activation of platelets and prothrombin in human thoracic ascending aortic aneurysm.
MedLine Citation:
PMID:  18292393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to investigate whether thoracic ascending aortic aneurysm (TAAA) induces platelet activation as mural thrombus participates in aortic dilatation in abdominal aortic aneurysm and TAAA are associated with rheological factors favoring coagulation activation. METHODS AND RESULTS: We studied the relation between coagulation activation and aortic diameter in Marfan patients (MFS) with various aortic diameters (n=52). We then studied patients presenting large aneurysms associated with bicuspid aortic valve (BAV) and degenerative form. Lastly, we used immunochemistry and biochemistry to investigate prothrombin/thrombin retention within the aortic wall. Microparticles, sGPV, tissue factor, and TAT complexes were increased in plasma from MFS with large aneurysms (>or=45 mm) compared to MFS with limited aortic dilatation (<45 mm). Similar elevations were observed in all patients with large aortic aneurysms, regardless of the etiology, the site of maximal aortic dilation, associated valvulopathy, risk factors, or treatments. P-selectin and platelet-bound fibrinogen were also increased, demonstrating platelet activation in large aneurysms. Significant increase in sCD146 plasma concentration suggested alteration of endothelium. CONCLUSIONS: Platelet activation occurs in patients with large aneurysms of the ascending aorta, is dependent on aortic dilation, and is associated with thrombin generation, part of which appears to be retained in mucoid degeneration areas.
Authors:
Ziad Touat; Laurent Lepage; Véronique Ollivier; Patrick Nataf; Ulrich Hvass; Julien Labreuche; Martine Jandrot-Perrus; Jean-Baptiste Michel; Guillaume Jondeau
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-21
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  28     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-04-18     Completed Date:  2008-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  940-6     Citation Subset:  IM    
Affiliation:
INSERM, U698, University Paris 7, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antigens, CD146 / metabolism
Aorta, Thoracic / pathology*
Aortic Aneurysm, Thoracic / etiology,  pathology*,  physiopathology*
C-Reactive Protein / metabolism
CD40 Ligand / metabolism
Case-Control Studies
Endothelium, Vascular / metabolism,  pathology,  physiopathology
Female
Fibrinogen / metabolism
Humans
Male
Marfan Syndrome / complications,  metabolism,  physiopathology
Middle Aged
P-Selectin / metabolism
Platelet Activation / physiology*
Prothrombin / metabolism*
Thrombin / metabolism
Vascular Cell Adhesion Molecule-1 / metabolism
Vasodilation / physiology*
Chemical
Reg. No./Substance:
0/Antigens, CD146; 0/P-Selectin; 0/Vascular Cell Adhesion Molecule-1; 147205-72-9/CD40 Ligand; 9001-26-7/Prothrombin; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein; EC 3.4.21.5/Thrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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