Document Detail

Dilated intercellular spaces: extending the reach of the endoscope.
MedLine Citation:
PMID:  15743350     Owner:  NLM     Status:  MEDLINE    
Two manuscripts in this issue utilize quantitative methods to analyze the association between gastroesophageal reflux disease (GERD) and dilated intercellular spaces (DIS) evident on transmission electron microscopy of the esophageal epithelium. One study of 20 patients found that, irrespective of whether or not a pH study was positive, all GERD patients who had responded to proton pump inhibitors therapy had intercellular space measurements that were at least twice normal. The other study demonstrated that DIS resolved with effective GERD therapy in essentially every instance. Both studies suggest that DIS are an objective structural marker of endoscopy-negative reflux disease.
Peter J Kahrilas
Publication Detail:
Type:  Comment; Editorial    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  100     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-03     Completed Date:  2005-04-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  549-50     Citation Subset:  IM    
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MeSH Terms
Dilatation, Pathologic
Extracellular Space
Gastroesophageal Reflux / drug therapy,  pathology*
Proton Pumps / drug effects
Reg. No./Substance:
0/Proton Pumps
Comment On:
Am J Gastroenterol. 2005 Mar;100(3):537-42   [PMID:  15743348 ]
Am J Gastroenterol. 2005 Mar;100(3):543-8   [PMID:  15743349 ]

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