| Dilated cardiomyopathy and acute liver injury associated with combined use of ephedra, gamma-hydroxybutyrate, and anabolic steroids. | |
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MedLine Citation:
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PMID: 15899737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anabolic-androgenic steroids are synthetic derivatives of testosterone that some athletes have used to enhance muscle mass and improve their athletic performance. Ephedrine is a potent sympathomimetic agent that can lead to cardiomyopathy similar to that seen with catecholamine excess. Adverse cardiovascular events attributed to anabolic steroid and ephedra use, such as arrhythmias, myocardial infarction, cardiomyopathy, and sudden death, are rarely reported. Bodybuilders have used gamma-hydroxybutyrate, a potent secretagogue of growth hormone, to promote muscle development. Although dilated cardiomyopathy is a known complication of excess growth hormone levels, it has not been associated with use of gamma-hydroxybutyrate. A healthy 40-year-old man was admitted to our hospital for new-onset congestive heart failure and severe acute hepatitis that developed several months after he began using anabolic-androgenic steroids, ephedra, and gamma-hydroxybutyrate supplements. Analysis with an objective causality assessment scale revealed a probable adverse drug reaction between the patient's use of anabolic steroids, ephedra, and gamma-hydroxybutyrate and the development of his cardiomyopathy and acute liver injury. |
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Authors:
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Brychan M Clark; Richard S Schofield |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Pharmacotherapy Volume: 25 ISSN: 0277-0008 ISO Abbreviation: Pharmacotherapy Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-18 Completed Date: 2005-09-02 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8111305 Medline TA: Pharmacotherapy Country: United States |
Other Details:
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Languages: eng Pagination: 756-61 Citation Subset: IM |
Affiliation:
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Department of Medicine, Wilford Hall USAF Medical Center, San Antonio, TX 78236, USA. brychan.clark@lackland.af.mil |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anabolic Agents / adverse effects* Cardiomyopathy, Dilated / chemically induced* Central Nervous System Depressants / adverse effects Drug Synergism Drug-Induced Liver Injury / etiology* Ephedra sinica / adverse effects* Human Growth Hormone / secretion Humans Liver Failure, Acute / chemically induced* Male Methandrostenolone / adverse effects Nandrolone / adverse effects, analogs & derivatives Sodium Oxybate / adverse effects* Steroids / adverse effects* Weight Lifting |
| Chemical | |
Reg. No./Substance:
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0/Anabolic Agents; 0/Central Nervous System Depressants; 0/Steroids; 12629-01-5/Human Growth Hormone; 360-70-3/nandrolone decanoate; 434-22-0/Nandrolone; 502-85-2/Sodium Oxybate; 72-63-9/Methandrostenolone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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