Document Detail


Dilantin-induced long-term bilateral total external ophthalmoplegia.
MedLine Citation:
PMID:  2939108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A young, healthy woman underwent craniotomy for the resection of a corpus callosum arteriovenous malformation. She was slow to awaken from anesthesia and was later noted to have a total external ophthalmoplegia. Her mental status quickly improved but the total ophthalmoplegia showed only minimal improvement for 2 weeks. After ruling out possible cerebrovascular and anesthetic complications, we concluded that the oculomotor impairment was due to postoperative toxic levels of Dilantin. Toxic Dilantin levels are known to rarely produce total ophthalmoplegia. In previously reported cases, this has always resolved with normalization of the serum Dilantin levels. This case represents the first report of Dilantin-induced ophthalmoplegia that took at least 3 months to resolve; it provides a detailed documentation of the course of ocular findings.
Authors:
C A Fredericks; S L Giannotta; A A Sadun
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of clinical neuro-ophthalmology     Volume:  6     ISSN:  0272-846X     ISO Abbreviation:  J Clin Neuroophthalmol     Publication Date:  1986 Mar 
Date Detail:
Created Date:  1986-06-06     Completed Date:  1986-06-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8109051     Medline TA:  J Clin Neuroophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  22-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Cerebral Angiography
Chronic Disease
Corpus Callosum / surgery
Female
Humans
Intracranial Arteriovenous Malformations / radiography,  surgery
Ophthalmoplegia / chemically induced*,  pathology
Phenytoin / administration & dosage,  adverse effects*,  blood
Postoperative Period
Premedication
Chemical
Reg. No./Substance:
57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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