| Dihydroorotic acid dehydrogenase activity in actinomycin-D-treated and normal chick embryos. | |
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MedLine Citation:
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PMID: 2852127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of actinomycin D on chick embryos cultivated in vitro by New's culturing method was studied. Exposure of chick embryos to actinomycin D (0.05 micrograms/ml) at the primitive streak stage (stage 4; Hamburger and Hamilton) for 6 h showed interference in orotic acid formation. The assay of the enzyme dihydroorotic acid dehydrogenase was carried out in both treated and control embryos. No enzymic activity was observed in actinomycin-D-treated embryos in contrast to the considerable activity in the controls. These observations suggest an interference by actinomycin D in the biogenesis of the enzyme dihydroorotic acid dehydrogenase. |
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Authors:
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S M Katdare; M Katdare; P N Joshi; L Mulherkar |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental cell biology Volume: 56 ISSN: 0304-3568 ISO Abbreviation: Exp. Cell Biol. Publication Date: 1988 |
Date Detail:
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Created Date: 1989-04-04 Completed Date: 1989-04-04 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7701827 Medline TA: Exp Cell Biol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 285-8 Citation Subset: IM |
Affiliation:
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Department of Zoology, University of Poona, Pune, India. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chick Embryo / enzymology* Dactinomycin / pharmacology* Dihydroorotate Oxidase / biosynthesis, metabolism* Oxidoreductases / metabolism* |
| Chemical | |
Reg. No./Substance:
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50-76-0/Dactinomycin; EC 1.-/Oxidoreductases; EC 1.3.3.1/Dihydroorotate Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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