| Dihydroergotoxine decreases blood pressure in spontaneously hypertensive rats by interacting with peripheral dopamine receptors. | |
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MedLine Citation:
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PMID: 3982223 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dihydroergotoxine (10 micrograms/kg s.c.) decreased mean carotid blood pressure in urethane-anaesthetized spontaneously hypertensive rats but failed to modify the same parameter in normotensive rats. The effect was statistically significant 20 min after the injection and relatively long lasting (up to 90 min). Pharmacological characterization of the phenomenon indicated that it is mediated by stimulation of dopamine receptors, since pretreatment with haloperidol, cis-flupentixol but not with trans-flupentixol, completely prevent the reduction in blood pressure induced by dihydroergotoxine. Moreover, a challenge dose of dihydroergotoxine did not reduce mean blood pressure values in spontaneously hypertensive rats pretreated with domperidone or (-)sulpiride, but not with (+)sulpiride. These results suggest that the ergot derivative modifies the cardiovascular system by interaction with peripheral dopamine receptors of the DA2 type. |
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Authors:
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M Memo; G Sagheddu; M O Carruba; P Spano |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 36 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-05-20 Completed Date: 1985-05-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1515-22 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Dihydroergotoxine / pharmacology* Domperidone / pharmacology Drug Interactions Flupenthixol / pharmacology Haloperidol / pharmacology Male Rats Rats, Inbred SHR Rats, Inbred WF Receptors, Dopamine / metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Dopamine; 11032-41-0/Dihydroergotoxine; 2709-56-0/Flupenthixol; 52-86-8/Haloperidol; 57808-66-9/Domperidone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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