Document Detail


Dihydroartemisinin-piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report.
MedLine Citation:
PMID:  18385345     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dihydroartemisinin-piperaquine (DHA-PPQ) is a promising new artemisinin combination treatment. There are no published data on the intentional use of the drug in pregnancy. Between June 2006 and January 2007, 50 Karen pregnant women with recurrent P. falciparum infections, despite 7-day treatments with quinine or artesunate (+/-clindamycin) or both, were treated with DHA-PPQ. This rescue treatment was effective and well tolerated and there was no evidence of toxicity for the mothers or the fetus. The PCR adjusted cure rate by Kaplan Meier analysis at day 63 was 92.2% (95% CI: 76.9-97.4).
Authors:
Marcus J Rijken; Rose McGready; Machteld E Boel; Marion Barends; Stephane Proux; Mupawjay Pimanpanarak; Pratap Singhasivanon; François Nosten
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  78     ISSN:  1476-1645     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-03     Completed Date:  2008-08-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  543-5     Citation Subset:  AIM; IM    
Affiliation:
Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Antimalarials / therapeutic use*
Artemisinins / therapeutic use*
Drug Therapy, Combination
Female
Fever / epidemiology
Gestational Age
Gravidity
Humans
Malaria, Falciparum / drug therapy*
Parity
Plasmodium falciparum / isolation & purification
Plasmodium vivax / isolation & purification
Pregnancy
Pregnancy Complications, Infectious / drug therapy*,  parasitology*
Quinolines / therapeutic use*
Retrospective Studies
Thailand
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Artemisinins; 0/Quinolines; 4085-31-8/piperaquine; 71939-50-9/dihydroquinghaosu

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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