| Dihydro-resveratrol--a potent dietary polyphenol. | |
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MedLine Citation:
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PMID: 20813524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dihydro-resveratrol (dihydro-R), a prominent polyphenol component of red wine, has a profound proliferative effect on hormone-sensitive tumor cell lines such as breast cancer cell line MCF7. We found a significant increase in MCF7 tumor cells growth rates in the presence of picomolar concentrations of this compound. The proliferative effect of dihydro-R was not observed in cell lines that do not express hormone receptors (MDA-MB-231, BT-474, and К-562). |
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Authors:
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Andrei A Gakh; Natalia Yu Anisimova; Mikhail V Kiselevsky; Sergey V Sadovnikov; Ivan N Stankov; Mikhail V Yudin; Konstantin A Rufanov; Mikhail Yu Krasavin; Andrey V Sosnov |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-05 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry letters Volume: 20 ISSN: 1464-3405 ISO Abbreviation: Bioorg. Med. Chem. Lett. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-20 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107377 Medline TA: Bioorg Med Chem Lett Country: England |
Other Details:
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Languages: eng Pagination: 6149-51 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Oak Ridge National Laboratory, Oak Ridge, TN 37831-6242, USA. gakhaa@ornl.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents, Phytogenic
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chemistry*,
pharmacology* Breast Neoplasms / drug therapy Cell Line, Tumor Cell Proliferation / drug effects* Dietary Supplements Female Flavonoids / chemistry, pharmacology Humans Neoplasms, Hormone-Dependent / drug therapy Phenols / chemistry, pharmacology Stilbenes / chemistry*, pharmacology* Wine |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Flavonoids; 0/Phenols; 0/Stilbenes; 0/polyphenols; 501-36-0/resveratrol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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