| Digoxin may provide protection against vasospasm in subarachnoid haemorrhage. | |
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MedLine Citation:
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PMID: 19436949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Vasospasm is a significant reason for poor clinical outcome in subarachnoid haemorrhage (SAH). One of the possible causes of vasospasm is attributed to the inhibition of Na(+)/K(+)-ATPase and increased intracellular calcium. Although digoxin, a cardiac glycoside (CG), inhibits the Na(+)/K(+)-ATPase, diverse and contradictory biological actions of CGs have also been reported. This study aimed to investigate the effect of digoxin on an experimental vasospasm after subarachnoid haemorrhage (SAH) in rats. METHODS: The rats used in the study were divided into normal, saline, SAH, and drug groups. A double-haemorrhage method was applied for the SAH groups. Normal saline or blood samples were injected into the cisterna magna. No surgical procedures were performed on the normal group. For the drug groups, daily digoxin was administered intraperitoneally after saline or blood injections. On days 3 and 7 after injections, the brains and basilar artery sections of all the groups were prepared for light-microscopic examination. The wall thickness and luminal area of the basilar artery were calculated by using medical imaging software. RESULTS: Increased wall thickness and reduced vessel luminal area were conspicuously significant in the SAH groups which did not receive digoxin. In SAH groups after digoxin administration, the vessel wall thickness decreased, and no significant change was found in vessel wall thickness when compared with the normal and saline groups. The vessel luminal area was not reduced in SAH after digoxin administration. CONCLUSIONS: These results suggest that digoxin administration in experimental SAH may have a beneficial effect on the protection against vasospasm. If further investigations support our results, the present study may offer a new insight into the treatment of SAH. |
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Authors:
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Murat Vural; T Erhan Cosan; Zuhtu Ozbek; Didem Cosan; Fezan Sahin; Dilek Burukoglu |
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Publication Detail:
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Type: Journal Article Date: 2009-05-13 |
Journal Detail:
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Title: Acta neurochirurgica Volume: 151 ISSN: 0942-0940 ISO Abbreviation: Acta Neurochir (Wien) Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-25 Completed Date: 2009-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151000 Medline TA: Acta Neurochir (Wien) Country: Austria |
Other Details:
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Languages: eng Pagination: 1135-41 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Medical Faculty, Eskisehir Osmangazi University, Dede Mah. Alp Konutlari, Alp-4, D-Blok, Daire-2, Eskisehir, Turkey. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basilar Artery / drug effects, pathology Digoxin / therapeutic use* Disease Models, Animal Enzyme Inhibitors / therapeutic use* Hypertrophy / drug therapy, physiopathology, prevention & control Muscle, Smooth, Vascular / drug effects, physiopathology Rats Rats, Sprague-Dawley Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors, metabolism Subarachnoid Hemorrhage / complications* Treatment Outcome Vasospasm, Intracranial / pathology, physiopathology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 20830-75-5/Digoxin; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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