Document Detail

Digoxin-like immunoreactive substance in nonoliguric hyperkalemia of the premature infant.
MedLine Citation:
PMID:  12660435     Owner:  NLM     Status:  MEDLINE    
Nonoliguric hyperkalemia of premature infants probably results from a transient inhibition of membrane-bound Na+/K+-ATPase during the first 24 h after birth. We hypothesized that the endogenous digitalis-like activity of the serum of premature infants, which inhibits the Na+/K+-ATPase, triggered hyperkalemia. Serum concentrations of potassium ([K+]) and of the digoxin-like immunoreactive substance ([DLIS]) were measured during the first 24 h after birth in 60 infants including 30 infants <30 gestational weeks. Contrary to our hypothesis, there was a negative linear correlation between [DLIS] at birth and [K+] 24 h after birth (r2 = 0.24, p < 0.002). 24 h after birth there was no correlation between [DLIS] and [K+]. Thus, a major role of DLIS in nonoliguric hyperkalemia could not be established.
Eva Mildenberger; Kathrin Oels; Karl Bauer; Martin Paul; Hans T Versmold
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biology of the neonate     Volume:  83     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2003  
Date Detail:
Created Date:  2003-03-27     Completed Date:  2003-10-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  182-7     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Department of Pediatrics, Universitätsklinikum Benjamin Franklin, Berlin, Germany.
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MeSH Terms
Circadian Rhythm
Digoxin / blood,  metabolism*
Extracellular Space / metabolism*
Hyperkalemia / blood,  etiology*,  metabolism*
Infant, Newborn
Intracellular Fluid / metabolism
Osmolar Concentration
Potassium / blood,  metabolism*
Saponins / blood,  metabolism*
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors*
Time Factors
Reg. No./Substance:
0/Cardenolides; 0/Saponins; 0/digoxin-like factors; 20830-75-5/Digoxin; 7440-09-7/Potassium; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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